声脉冲辐射力弹性成像技术检测正常儿童肝脏弹性

Acoustic radiation force impulse imaging in measurement of liver elasticity in normal children

目的采用声触诊组织量化（VTQ）技术检测正常儿童肝脏弹性,比较不同年龄阶段正常儿童肝脏剪切波速度（SWV）测值。方法对458名正常儿童进行声脉冲辐射力弹性成像（ARFI）,分为新生儿组（0～28天）71名、婴儿组（29天≤年龄〈1岁）53名、幼儿组（1岁≤年龄〈3岁）61名、学龄前组（3岁≤年龄〈6岁）86名、学龄期组（6岁≤年龄〈10岁）112名、青春期组（10岁≤年龄〈18岁）75名,比较各组间SWV差异;对40名青春期组儿童于平静呼吸状态下和屏气状态下测量SWV,分析呼吸动度对SWV值的影响;对35名学龄期及60名青春期儿童分别于不同取样深度测量SWV值,比较不同取样深度SWV值差异。结果所有儿童肝脏平均SWV值为（1.11±0.08）m/s。各组间SWV值差异无统计学意义（P〉0.05）;呼吸动度和取样深度对SWV测值均无明显影响（P均〉0.05）。结论 ARFI可用于儿童肝脏弹性检测,不同年龄段儿童肝脏SWV值无明显差异,以（1.11±0.08）m/s作为正常儿童标准肝脏弹性测值,可为儿童肝纤维化的研究提供参考。

Objective To measure the liver elasticity in normal children with virtual touch tissue quantification（VTQ）and compare the shear wave velocity（SWV）among children of different age.Methods Totally 458 children were divided into neonatal group（0—28days,n=71）,baby group（≥29days and〈 1year,n=53）,children＇s group（≥1and 〈3years,n=61）,preschool group（≥3and〈6years,n=86）,school-age group（≥6and〈10years,n=112）,adolescence group（≥10and 〈18years,n=75）and underwent acoustic radiation force impulse imaging（ARFI）.SWV values were compared between different groups.SWV value was measured under eupnea and apnea in 40 adolescence children to examine the influence of breathing.SWV value of different sample depth was measured and compared in 35school-age children and 60 adolescence children,respectively.Results The mean SWV value of all the children was（1.11±0.08）m/s.There were no significant differences of SWV among different age groups（P〉0.05）,Neither breathing nor sample depth had significant influence on SWI values（all P〉0.05）.Conclusion ARFI can be used to measure the liver elastography in normal children and there are no significant difference of SWV among children of different age.Taking（1.11±0.08）m/s as SWI values of normal children can provide a reference for researches of hepatic fibrosis in children.