吸入一氧化氮辅助治疗急性低氧性呼吸衰竭的效果分析

The effect analysis of inhaled nitric oxide on the treatment of acute hypoxic respiratory failure

目的探讨吸入一氧化氮辅助治疗急性低氧性呼吸衰竭的效果分析。方法将130例急性低氧性呼吸衰竭新生儿根据治疗方法不同分为治疗组和对照组，每组65例，两组均给予常规机械通气与药物治疗，在此基础上治疗组给予吸入一氧化氮治疗。比较两组疗效、氧合指数、动脉与肺泡氧分压比值；治疗后随访6个月，观察预后情况，包括死亡、并发症等。结果治疗组总有效率明显高于对照组[95．4％（62／65）比84．6％（55／65）]，差异有统计学意义（P〈0．05）。治疗组治疗后氧合指数和动脉与肺泡氧分压比值明显优于对照组[（365．38±45．27）mmHg（1mmHg=0．133kPa）比（267．77±50．33）mmHg、0．38±0．12比0．27±0．10]，差异有统计学意义（P〈0．05）。所有新生儿治疗后随访6个月，治疗组与对照组病死率比较差异无统计学意义（P〉0．05）。治疗组并发症发生率明显低于对照组[7．7％（5／65）比21．5％（14／65）]，差异有统计学意义（P〈0．05）。结论吸入一氧化氮辅助治疗急性低氧性呼吸衰竭能有效提高疗效，改善预后，其机制可能与改善血气指标有关。

Objective To discuss the effect of inhaled nitric oxide on the treatment of acute hypoxic respiratory failure. Methods One hundred and thirty newborns of acute hypoxic respiratory failure were divided into treatment group and control group with 65 cases each according to the treatment method. Both groups received conventional mechanical ventilation and drug therapy, and the treatment group received inhaled nitric oxide therapy on this basis. The effect, oxygenation index, arteries and alveolar oxygen partial pressure ratio was compared between two groups. All the cases were followed up for 6 months after treatment, and the prognosis including death, complication,etc was observed. Results The total effective rate in treatment group was higher than that in control group [ 95.4% （62/65） vs. 84.6% （55/65）], and there was significant difference（P 〈 0.05 ）. The oxygenation index, arteries and alveolar oxygen partial pressure ratio in treatment group was better than that in control group [ （365.38 ± 45.27） mmHg （ 1 mmHg = 0.133 kPa） vs. （267.77 ± 50.33 ） mmHg, 0.38 ± 0.12 vs. 0.27 ± 0.10 ], and there was significant difference （P 〈 0.05 ）. After 6 months＇ follow-up, there was no significant difference in mortality between two groups （P 〉 0.05）. The complications rate in treatment group was lower than that in control group [7.7%（5/65 ） vs. 21.5%（ 14/65 ） ], and there was significant difference （P 〈 0.05）. Conclusion Inhaled nitric oxide in adjuvant treatment of acute hypoxic respiratory failure can effectively improve the efficacy and improve prognosis,which may be related with the improvement in blood gas analysis.