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新型口服抗凝药物在急性冠状动脉综合征中的应用

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摘要 部分急性冠状动脉综合征(acute coronary syndrome,ACS)患者在事件后的数周和数个月内仍有可能再次发生血栓事件,因此抑制凝血酶生成和活化是ACS治疗的重要组成部分。虽然普通肝素、低分子量肝素、磺达肝癸钠和比伐芦定用于治疗ACS均可获益,但由于需胃肠道外给药因而限制了出院后患者的长期使用。
出处 《中国医师进修杂志》 2014年第34期71-73,共3页 Chinese Journal of Postgraduates of Medicine
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参考文献15

  • 1Sorensen R, Hansen ML, Abildstrom SZ, et al. Risk of bleeding in patients with acute myocardial infarction treated with different combinations of aspirin, clopidogrel, and vitamin K antagonists in Denmark: a retrospective analysis of nationwide registry data[J]. Lancet,2009,374(9706) : 1967-1974.
  • 2Costopoulos C, Niespialowska-Steuden M, Kukreja N, et al. Novel oral anticoagulants in acute coronary syndrome [J]. Int J Cardiol, 2013,167(6) :2449-2455.
  • 3APPRAISE Steering Committee and Investigators, Alexander JH, Becker RC, et al. Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trim [J]. Circulation, 2009,119(22) :2877-2885.
  • 4Alexander JH, Lopes RD, James S, et al. Apixaban with antiplatelet therapy after acute coronary syndrome [J]. N Engl J Med,2011,365(8) : 699-708.
  • 5Wong H, Nunokawa N, Song JC, et al. Rivaroxaban: a direct factor Xa inhibitor for VTE prophylaxis in patients undergoing total knee or hip replacement surgery [J]. Formulary,2009,44 (7) : 226-236.
  • 6EINSTEIN Investigators, Bauersachs R, Berkowitz SD, et al. Oral rivaroxaban for symptomatic venous thromboembolism[ J]. N Engl J Med, 2010,363 (26) : 2499-2510.
  • 7Patel MR, Mahaffey KW, Garg J,et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation [J]. N Engl J Med, 2011,365(10) : 883-891.
  • 8Mega JL, Braunwald E, Mohanavelu S,et al. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS- TIMI 46) : a randomised, double-blind, phase II trial [ J ]. Lancet, 2009,374(9683 ) :29-38.
  • 9Mega JL, Braunwald E, Wiviott SD, et al. Rivaroxaban in patients with a recent acute coronary syndrome [J]. N Engl J Med, 2012,366( 1 ) :9-19.
  • 10Heeringa M, Groenendaal D, Strabach G, et al. The pharmacokinetics of YM150, an oral direct factor Xa inhibitor, are not affected to a clinically relevant degree by strong inhibition or induction of CYP3A4 and P-gp [ J ]. J Thromb Hemost, 2011,9 Suppl 2: S359-360.

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