期刊文献+

成釉细胞瘤组织中β-catenin基因的表达变化 被引量:1

下载PDF
导出
摘要 目的观察成釉细胞瘤组织中β-连环蛋白(β-catenin)基因的表达变化。方法采用RT-PCR法对8例份成釉细胞瘤(AB)组织、10例份牙源性角化囊性瘤(KCOT)组织及6例份正常口腔黏膜组织中的β-catenin mRNA进行检测。结果 AB组织、KCOT组织、正常口腔黏膜组织中β-catenin mRNA的相对表达量分别为1.333±0.258、1.378±0.211、0.952±0.300;AB组织与KCOT组织中β-catenin mRNA的表达量与正常口腔黏膜组织相比,P均<0.05;AB组织与KCOT组织中β-catenin mRNA的表达量相比,P>0.05。结论与正常口腔黏膜组织相比,AB组织中β-catenin mRNA表达增强,其在AB组织中的异常表达可能与AB的发生发展及其生物学行为密切相关,可作为AB的诊断、治疗和预后评估的一个指标。
出处 《山东医药》 CAS 2014年第43期78-79,共2页 Shandong Medical Journal
基金 河北省科技支撑计划项目(201121054)
  • 相关文献

参考文献11

  • 1Siriwardcna BSMS, Tennakoon TMPB, Tilakaratne WM. Relative tYequency of odontogenic tumors in Sri Lanka: analysis of 1677 ca- ses[ J]. Palhol Res Praet, 2012,208(4) :225-230.
  • 2Osterne RL, Brito RG, Aires AP, et al. Odontogenic tumot's: a 5- year retrospective study in a Brazilian population and analysis of 3 406 cases reported in the literature[ J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011,111 (4) :474- 481.
  • 3Pinheiro JJV, Freitas VM, Moretti AIS, et al. Local invasiveness of amelohlastoma. Role played by matrix metalloproteinases and proliferative activity[ J ]. Histopathology, 2004,45 ( 1 ) :65-72.
  • 4Aires Pereira KM, do Amaral BA, (los Santos BR, et al. lmmuno- histochemical expression of E-cadherin and beta-catenin in amelo- blastomas and tooth germs [ J ]. Oral Sarg Oral Med Oral Pathol Oral RadiOl Endod, 2010,109(3 ) :425-431.
  • 5Rosa IrE, Jaeger MM, Jaeger RG. Morphometric study of nucleolar organiser regions in ameloblastoma and basal cell carcinoma[ J ]. Oral Oncol, 1997,33(3) :209-214.
  • 6张秋红,赵培荣,刘进忠.成釉细胞瘤组织CyclinD1、CDK4的表达及意义[J].山东医药,2005,45(24):60-61. 被引量:1
  • 7蒋欣,孙卫华,张亚军.子宫颈鳞状细胞癌组织中β-catenin、Cyclin D1的表达变化及意义[J].山东医药,2013,53(27):17-19. 被引量:3
  • 8Siqueira AS, Carvalho MRD, Munteiro ACD, el al. Matrix metal- loprnteivlases, TIMPs and groh factors regulating ameloblastoma hehaviour[ J]. Histopathology, 2010, 57( 1 ) : 128-137.
  • 9Oliva E, Sarri6 D, Braehtel EE, et al. High frequency of betacate- nin mutations in borderline endomet rioid tumours of the ovary[ J ]. J Pathol, 2006,208 ( 5 ) :708-713.
  • 10Cecim RI, Carmo HA, Kataoka MS, eL al. Expression of mo|e- eules related to AKT pathway as putative regulators of amelohlas- toma local invasiveness [ J ]. J Oral Pathol Med, 2014,43 ( 2 ) : 143-147.

二级参考文献27

  • 1郑健,郭美君,王丽岩.β连环蛋白在妇科肿瘤中的研究进展[J].国外医学(妇产科学分册),2004,31(5):311-313. 被引量:2
  • 2龚玲玲,李红英,曾俊.宫颈癌中α/β-连接素的联合表达及意义[J].临床与实验病理学杂志,2005,21(1):62-65. 被引量:14
  • 3王莉,张帆,吴平平,姜叙诚,郑林,于颖彦.β-catenin在胃癌增殖和浸润中的作用[J].临床与实验病理学杂志,2006,22(1):49-53. 被引量:3
  • 4陈意生 史景泉主编.肿物分子细胞生物学[M].北京:人民军医出版社,2002.61.
  • 5Pripatnanont P,Song Y, Harris M, et al. In situ hybridization and immunocytochemical localisation of osteolytic cytokines and adhesion molecules in ameloblastomas. J Oral Pathol Med, 1998,27(10): 496-500.
  • 6Salo T, Kainulainen T, Pafikka M. Expression of laminin - 5 in ameloblastomas and human fetal teeth. J Oral Pathol Med, 1999;28(8) : 337-343.
  • 7Birchmeier W. E - cadherin as a tumor ( invasion ) Suppressor gene. Bioessays 1995 ; 17(2) : 97 -99.
  • 8Downer CS, Speight PM. E - cadherin expresson in normal, hyperplastic and malignant oral epithelium. Oral Oncol. Eur. J. Cancer,1993,29B(4): 303 -305.
  • 9Lo Muzio L,Staibano S,Pannone G,et al. Beta - and Gamma-Catenin Expression in Oral Squmamous cell carcinoma. Amicancer Research, 1999,19(5 B) : 3817 - 3826.
  • 10Kumamoto H,Ooya K. Expression of E - cadherin and α - cate-nin in epithelial odontogenic tumors: an immunohistochemical study. J Oral Pathol Meal,1999, 28(4) : 152 - 157.

共引文献7

同被引文献13

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部