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流感病毒融合肽磁共振研究进展 被引量：3

Structure and Function of Influenza Virus Fusion Peptide Studied by Nuclear Magnetic Resonance Spectroscopy
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摘要 流感病毒融合肽在流感病毒感染宿主细胞的过程中扮演关键角色,解析其三维结构是了解病毒融合机制的关键.融合肽结构的研究历经十几年,期间提出了多种融合模型和假说,至今仍然是科学家们感兴趣的热点问题.核磁共振方法是研究融合肽结构的主要手段之一,该文综述了该领域近几年的重要进展,以期对流感病毒融合肽的融合机制有更深入的认识. The influenza fusion peptide plays a pivotal role in the fusion process of the viral membrane with the host-cell endosomal membrane. Recent success of solving the structure of influenza hemagglutinin fusion peptide has led to a new understanding of the fusion mechanism. Although a few hypotheses have been proposed, it is still of great interest to investigate the structure-function relationship of the fusion peptide. In this paper, the progresses in the field for the last decade is reviewed.
作者 杜天鹏 张子微 曾丹云 刘买利 姜凌
机构地区 波谱与原子分子物理国家重点实验室、武汉磁共振中心中国科学院武汉物理与数学研究所 中国科学院大学
出处 《波谱学杂志》 CAS CSCD 北大核心 2014年第4期596-607,共12页 Chinese Journal of Magnetic Resonance
基金 国家自然科学基金资助项目(21173257)
关键词 液体核磁共振 流感病毒融合肽 三维结构 融合机制 NMR influenza fusion peptide 3D structure mechanism of fusion process
分类号 O482.53 [理学—固体物理]
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参考文献48

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共引文献8

同被引文献63

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波谱学杂志
2014年 第4期

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