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Notch信号通路在风湿性心脏病炎症相关发病机制中的研究进展 被引量：4

Research into Notch Signal Pathway and Inflammation Related Pathogenesis of Rheumatic Heart Disease
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摘要 风湿性心脏病是一种以长期、反复发作的风湿性心瓣膜炎导致慢性心瓣膜损害的疾病。炎症在风湿性心脏病的发生和发展中起到了重要作用。通过近年来的研究发现,Notch信号通路与高血压、先天性心脏病如二叶式主动脉瓣、心瓣膜钙化以及室间隔缺损等疾病的发生和发展相关。Notch信号通路与淋巴细胞发育和增殖及炎症过程有密切关系,考虑Notch信号通路在风湿性心脏病的发生和发展中起的重要作用。 Rheumatic valvulitis is a type of rheumatic heart disease that is characterized by repeated and lengthy episodes. An impor- tant factor in the development and occurrence of rheumatic heart disease is inflammation. Recent studies have found that the Notch signaling pathway is associated with congenital heart disease, proliferation of lymphocytes and inflammatory processes. The connection between the Notch signaling pathway, cardiac events and itfflammation, may indicate that the Notch signaling pathway has a role in the occurrence and development of rheumatic heart disease.
作者 秦亚录 刘天虎
机构地区 郫县人民医院心内科
出处 《心血管病学进展》 CAS 2014年第6期740-743,共4页 Advances in Cardiovascular Diseases
基金 四川省卫生厅科研课题(120277)
关键词 NOTCH信号通路 风湿性心脏病 炎症 发病机制 Notch signaling pathway rheumatic heart disease inflammation pathogenesis
分类号 R541.2 [医药卫生—心血管疾病]
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参考文献26

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同被引文献48

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心血管病学进展
2014年 第6期

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