CEA、CA199、CA724、CA242、CA125、CA50对消化道肿瘤的诊断价值

Diagnostic Value of CEA、CA199、CA724、CA242、CA125 and CA50 in Gastrointestinal Tumors

目的探讨CEA、CA199、CA724、CA242、CA125、CA50对胰腺癌、结肠癌、胃癌、胆囊癌等消化道肿瘤的诊断价值。方法采用电化学方法及EIA法,检测648例消化道肿瘤患者的CEA、CA199、CA724、CA242、CA125、CA50水平。结果治疗前467例恶性肿瘤患者中肿瘤标志物总阳性检出率为76.66%,高于良性肿瘤患者的39.23%。治疗后235例肿瘤标志物假阳性检出患者肿瘤复发率,高于肿瘤标志物阴性检出患者的31.24%,P<0.05,有统计学意义。结论CEA、CA199、CA724、CA242、CA125、CA50在恶性肿瘤中检出率较高,并对判断假阳性检出患者复发有一定意义。

Objective To study the diagnostic value of CEA、CA199、CA724、CA242、CA125 and CA50 in gastrointesti-nal tumor such as spancreatic cancer ,colon cancer,gastric cancer and gallbladder carcinoma .Methods CEA、CA199、CA724、CA242、CA125 and CA50 of 648 cases of patients with gastrointestinal tumors were detected .Results Before treatment ,total pos-itive detection rate of tumor markers for malignant tumor patients was 76.66%,which was significantly higher than that of benign tumor patients（39.23%）.Recurrence rates of 235 patients with false positive detection of tumor markers were higher than pa-tients with negative detection （31.24%）,it had statistical significance,P〈0.05.Conclusion CEA、CA199、CA724、CA242、CA125 and CA50 have high detection rate in malignant tumors ,and they have predictive value on the recurrence of recovered pa-tients with false positive detection .