淋巴细胞绝对计数对多发性骨髓瘤患者的生存影响

Effect of Absolute Lymphocyte Count on Survival of Multiple Myeloma Patients

目的探讨淋巴细胞绝对计数对多发性骨髓瘤患者的生存影响。方法回顾性研究多发性骨髓瘤患者60例,查阅并记录患者的相关指标,根据患者的ALC平均数将患者分为ALC较高组和ALC较低组,分析ALC对多发性骨髓瘤患者的生存影响。结果 ALC较高组患者的年龄和β2-MG含量明显低于ALC较低组(P<0.05),而ALC较高组患者LDH、OS和有效率明显高于ALC较低组(P<0.05);2组患者在性别、ALB、D-S分期、ISS分期方面无统计学差异(P>0.05)。结论 ALC高的患者疗效和OS较好,推测ALC可能是多发性骨髓瘤患者生存的独立因素之一。

Objective To explore the effect of absolute lymphocyte count on survival of multiple myeloma patients . Methods 60 cases of primary myeloma patients were retrospectively analyzed ,related indexes were checked and record .Accord-ing to the average number of patient ’s ALC,the patients were divided into high ALC group and low ALC group ,and the effect of ALC on survival of patients with multiple myeloma was analyzed .Results Age and β2-MG of the high ALC group were lower than those of the low ALC group（P〈0.05）.The LDH,OS and effective rates of patients in the high ALC group were significantly higher than those of the low ALC group;there were no statistically significant differences between the 2 groups in gender ,ALB,D-S stage,and ISS.Conclusion Patients with higher ALC has better efficacy and OS which suggests that ALC may be one of the independent factors affecting multiple myeloma patient ’s survival.