RORγt和IL-17在口腔扁平苔藓中的表达及相关性分析

Expression and Correlation Analysis of RORγt and IL-17 in Oral Lichen Planus

目的研究维甲酸相关核孤儿受体γt(Retinoid-related orphan receptor gamma-t,RORγt)和白介素17(Interleukin 17,IL-17)在口腔扁平苔藓(Oral lichen planus,OLP)病变组织中的表达,为OLP的发病机制及治疗研究提供实验依据。方法采用免疫组化方法,检测30例口腔扁平苔藓病变组织及30例正常口腔黏膜组织中RORγt和IL-17的表达情况。结果 RORγt在固有层中OLP组的表达高于正常口腔黏膜组(P<0.05);IL-17在OLP组中的上皮层和固有层中的表达均高于正常口腔黏膜组(P<0.05)。RORγt和IL-17在OLP组上皮层、固有层中表达均呈正相关(r=0.390和0.593,P=0.03和0.01)。结论 RORγt和IL-17与OLP病变的发生发展有一定关系。

Objective To investigate the expression o f RORγt and IL - 17 in OLP and their correlation , and to provide a feasible theoretically basis for the pathogenesis and treatment of OLP. Methods The epithelium and lamina propria from 30 cases of oral lichen planus and 30 cases of normal oral mucosa were adopted. Im- munihistochemical method was used to detect the expression levels of RORγt and IL - 17. Results The ex- pression levels of RORγt in OLP group were significantly higher than that in normal oral mucosa group （P 〈 0.05 ）. The expression levels of IL - 17 in both epithelium and lamina propria of OLP group were significantly higher than that in normal oral mucosa group （P 〈 0.05 ）. Conclusion RORγt and IL - 17 may have some correlation with the pathogenesis and progress of oral lichen nlanus.