“三阴”型乳腺癌中Snail蛋白的表达及意义

Expression and Significance of the Snail Protein in Patients with Triple-negative Breast Cancer

目的研究Snail蛋白在"三阴"型乳腺癌组织中的表达及与患者一般临床特征、病理参数的关系,探讨其对"三阴"型乳腺癌复发转移及预后的影响。方法采用免疫组化SP法检测40例"三阴"型乳腺癌组织及20例癌旁正常组织中Snail蛋白的表达水平,并分析其水平与临床病理参数、复发转移及预后的关系。结果1Snail蛋白在"三阴"型乳腺癌组织中阳性率高于癌旁正常组织(55.0%vs 25.0%,P<0.05);2Snail蛋白的阳性表达愈高,淋巴结愈易转移、临床分期愈晚、复发转移率愈高、5年生存率愈低(P<0.05);3经Cox比例风险模型分析显示原发肿块大小、腋窝淋巴结转移数目、Snail蛋白的表达及临床分期为"三阴"型乳腺癌患者预后的独立危险因素。结论 "三阴"型乳腺癌组织中Snail蛋白高表达,Snail蛋白可能参与了乳腺癌的发生发展,并且有可能作为判断"三阴"型乳腺癌复发、转移及预后的生物学指标。

Objective To investigate the expression of Snail protein in patients with the triple - negative breast cancer and its relationship with clinical features, pathologic parameters and to explore its impact on the triple - negative breast cancer recurrence, metastasis and prognosis. Methods Snail protein expression levels were detected in 40 patients with triple - negative breast cancer and 20 normal controls by SP immunohisto- chemical method. The relationship between expression levels and elinicopathological parameters, recurrence, metastasis and prognosis was analyzed. Results ① Snail protein expression rate in the triple - negative breast cancer was 55.0% and it was significantly higher than that in the adjacent normal tissues （P 〈 0. 05 ）. ② The higher Snail protein expression was, the more easily lymph node metastasis occurred, the later clinical stage was, the higher recurrence rate was and the lower 5 - year survival rate was （P 〈 0.05 ）. ③Cox proportional hazards model analysis showed that primary tumor size, number of metastatic axillary lymph nodes, Snail pro- tein expression and clinical stage were independent risk factors for prognosis in triple - negative breast cancer. Conclusion Snail protein overexpression was found in triple -negative breast cancer. It suggested that Snail protein might be involved in the development of breast cancer.