蒙古族牧民血清瘦素水平与肥胖度的关系

Relationship between the serum leptin levels and obesity degree in Mongolia nationality

目的：探讨牧区蒙古族牧民血清瘦素水平与年龄、性别及肥胖的关系。方法用放射免疫分析法测定150例蒙古族正常非肥胖和50例超重或肥胖个体[体质量指数（BMI）≥25]的血清瘦素水平。结果蒙古族牧民正常非肥胖者平均瘦素浓度男性为（2．25±1．13）μg／L，女性为（6．76±3．60）μg／L；超重或肥胖者平均瘦素浓度男性为（4．92±2．12）μg／L，女性为（16．20±5．42）μg／L，女性较男性高2～3倍。血清瘦素水平与 BMI 显著相关（男子 r ＝0．70，P 〈0．01；女子 r ＝0．62，P ＜0．01）。结论蒙古族牧民超重和肥胖个体瘦素浓度升高，BMI、脂肪含量、性别和年龄是影响血清瘦素浓度的主要因素。

Objective To explore the serum leptin level of Mongolia nationality herdsman with age,sex and obesity.Method The leptin level of 1 50 cases of Mongolia normal people and 50 cases overweight or obese individu-als [body mass index （BMI）≥25]were measured by radioimmunoassay.Results The serum leptin concentration of Mongolia nomads normal male and female were （2.25 ±1 .1 3）μg/L,（6.76 ±3.60）μg/L,respectively,The serum leptin concentration of overweight or obese male and female were （4.92 ±2.1 2）μg/L,（1 6.20 ±5.42）μg/L respec-tively.The serum leptin in female was 2 -3 times higher than that in male.The serum leptin level was positively cor-related with BMI （male r =0.70,P 〈0.01 ;female r =0.62,P 〈0.01 ）.Conclusion The majority of obese individ-uals have leptin resistance.