深圳龙华地区600例健康成人网织红细胞血红蛋白含量调查

Investigation of Reticulocyte Haemoglobin Content of 6 0 0 Cases of Healthy Adults in Longhua Area of Shenzhen

目的建立深圳龙华地区健康成人网织红细胞血红蛋白含量（reticulocytehaemoglobincontent，CHr）参考值区间，并分析其临床意义。方法采用 Sysmex XN-9000全自动血细胞分析仪检测600例健康成人血中CHr含量，建立 CHr参考区间；同时检测40例缺铁性贫血患者（iron deficiency anemia，IDA）血中 CHr含量作对照分析。结果18-30岁，31-40岁，41-50岁，51-60岁及＞60岁健康男性与女性血中CHr含量分别为36.35±3.26 pg和33.95±2.81 pg，36.02±3.01 pg和34.15±3.14 pg，36.41±2.76 pg和34.21±2.67 pg，35.96±3.06 pg和33.83±3.04 pg及36.09±2.86 pg和34.10±2.89 pg，同性别不同年龄组之间差异均无统计学意义（t＝1.34-1.82，P 均＞0.05），不同性别相同年龄组之间差异有统计学意义（t＝4.62-5.26，P 均＜0.05）；男性和女性 CHr含量参考区间分别为36.12±3.16 pg和34.05±2.94 pg，男性高于女性，结果之间差异有统计学意义（t＝6.792，P＜0.05）；IDA患者男性和女性 CHr含量分别为24.72±3.91 pg和22.63±3.76 pg，明显低于健康人群，结果之间差异有统计学意义（t＝11.29-13.02，P＜0.01）。结论深圳龙华地区不同性别健康成人的CHr含量参考区间存在差异，男性高于女性；IDA患者血中 CHr明显低于正常人群。因此，建立不同性别健康成人的CHr含量参考区间，对贫血的诊断、鉴别诊断、疗效判断以及早期监测造血功能恢复的程度具有重要的临床价值。

Objective To establish healthy adults in shenzhen longhua district reticulocyte red blood cell hemoglobin content of normal reference value range （CHr）,and analyze its clinical significance.Methods By Sysmex XN-9000 automatic blood cell analyzer to detect CHr content in the blood,and 600 healthy adults to establish CHr reference range.At the same time detection of 40 patients with iron deficiency anemia （IDA）CHr content in the blood to contrast analysis.Results 18-30, 31-40,41-50,51-60 and 〉60 years old healthy male and female CHr content in the blood,respectively 36.35±3.26 pg and 33.95±2.81 pg,36.02±3.01 pg and 34.15±3.14 pg,36.41±2.76 pg and 34.21± 2.67 pg,35.96±3.06 pg and 33.83±3.04 pg,36.09±2.86 pg and 34.10±2.89 pg,with gender differences between different age groups had no statisti-cal significance （t=1.34-1.82,P〉0.05）,the difference was statistically significant between different genders is the same age group （t=4.62-5.26,P〈 0.05）.CHr levels in both men and women respectively reference range 36.12±3.16 pg and 34.05±2.94 pg,men than women,the results between the difference was statistically significant （t=6.792,P〈0.05）.Pa-tients with IDA CHr levels in both men and women,respectively 24.72±3.91 pg and 22.63±3.76 pg,significantly lower than healthy people,the results between the difference was statistically significant （t=11.29-13.02,P〈0.01）.Conclusion Shenzhen longhua area different gender differences between healthy adults of CHr content reference interval,men than women.IDA patients serum CHr significantly lower than the general population.Therefore,the establishment of different gender healthy adults of CHr content reference interval,diagnosis,differential diagnosis,curative effect judgment of anemia and early monitoring the extent of the hematopoietic function recovery has important clinical value.