无创正压通气辅助治疗慢性阻塞性肺病急性加重期患者的临床观察

Clinical observation of noninvasive positive pressure ventilation therapy in treatment of acute exacerbation of Patient wiht COPD

目的:探讨应用无创正压通气(NIPPV)治疗慢性阻塞性肺病(COPD)急性加重期患者的临床疗效。方法:选择COPD急性加重期患者68例,随机分为对照组和NIPPV组,对照组患者34例,采用常规治疗;NIPPV组患者34例,采用常规联合NIPPV辅助治疗。观察两组患者症状、体征及Pa CO2、Pa O2、p H值等指标。结果:与治疗前相比,两组患者症状、体征均有好转,Pa CO2、Pa O2、p H值均有改善(P<0.01);上述指标两组患者组间比较,NIPPV组优于对照组,差异有统计学意义(P<0.05)。结论:应用无创正压通气辅助治疗COPD急性加重期病例的临床疗效优于常规治疗,值得推广。

Objective： To investigate the clinical efficacy of noninvasive positive pressure ventilation （ NIPPV ） therapy in treatment of acute exacerbation of Patients wiht chronic obstructive pulmonary disease （ COPD） . Methods：68 patients with COPD at acute exacerbation stage were randomly divided into control group and NIPPV group, 34 cases in each group. Control group used the conventional treatment;while NIPPV group received conventional treatment and assisted NIPPV therapy. The symptoms, signs and PaCO2 , PaO2 , pH value and other indicators of the two groups were observed. Results：Compared with those before the treatment, the symptoms and signs of the two groups were improved, and PaCO2, PaO2, and pH value were also improved （P〈0. 01）. Compared with control group, NIPPV group had better indicators, and the differences were significant （P〈0. 05）. Conclusions： NIPPV in the treatment of acute exacerbation of COPD has a better clinical efficacy than the conventional treatment, and is worthy of promotion.