摘要
目的:探讨丹参注射液联合常规治疗对小儿喘息性支气管炎反复发作的临床疗效。方法采用前瞻性研究方法,选择2012年1月至2014年7月河南省人民医院收治的喘息性支气管炎患儿55例,按随机原则分为中西医结合治疗组30例和常规治疗组25例;同期选取本院健康体检小儿18例为健康对照组。常规治疗组给予休息、吸氧、抗感染、补液、雾化吸入等常规治疗;中西医结合治疗组在常规治疗基础上加用丹参注射液0.4 mL · kg^-1· d^-1,每日1次,共14 d。观察常规治疗组和中西医结合治疗组患者喘息缓解时间和肺部啰音消失时间,并观察3组受试者呼出气一氧化氮(FeNO)水平。结果中西医结合治疗组喘息缓解时间及肺部啰音消失时间均较常规治疗组明显缩短〔喘息缓解时间(d):2.3±0.8比5.2±1.1,肺部啰音消失时间(d):6.8±1.5比8.4±1.1,均P<0.01〕。中西医结合治疗组及常规治疗组治疗前FeNO均明显高于健康对照组(×10^-9:30.3±9.5、30.4±8.2比13.6±3.4,均P<0.01),治疗后中西医结合治疗组和常规治疗组FeNO均明显降低,且以中西医结合治疗组变化更显著(×10^-9:18.6±4.7比24.0±6.8,P<0.01)。结论丹参注射液结合常规治疗可显著下调FeNO,从而减轻气道炎症,有效地缓解喘息性支气管炎的发作。
Objective To study the therapeutic effect of Danshen injection combined with conventional therapy on children with recurrent asthmatic bronchitis. Methods A prospective study was conducted. Fifty-five children with asthmatic bronchitis admitted in People's Hospital of Henan Province from January 2012 to July 2014 were enrolled and randomly divided into a integrative Chinese and western medicine group(30 cases)and a conventional therapy group(25 cases);in the same period,18 healthy children having passed physical examinations were chosen as the healthy control group. In the conventional therapy group,rest,oxygen inspiration,anti-infection, fluid supplement and aerosol inhalation,etc. were given,while in the integrative Chinese and western medicine group,based on the similar conventional therapies,additionally Danshen injection 0.4 mL · kg^-1 · d^-1 was given,once per day for a total of 14 days. The wheezing remission time and the pulmonary rale extinction time were observed in the two patient groups,and the fractional exhaled nitric oxide(FeNO)content was investigated in the three groups. Results The wheezing remission time and the pulmonary rale extinction time of the integrative Chinese and western medicine group were obviously shortened compared with those in the conventional therapy group〔the wheezing remission time(days):2.3±0.8 vs. 5.2±1.1,the pulmonary rale extinction time(days):6.8±1.5 vs. 8.4±1.1,both P〈0.01〕. The contents of FeNO in the integrative Chinese and western medicine group and the conventional therapy group before treatment were significantly higher than those in the healthy control group(×10^-9:30.3±9.5,30.4±8.2 vs. 13.6±3.4,both P〈0.01),but after treatment the FeNO levels of both patient groups were markedly lowered,and the degree of change in integrative Chinese and western medicine group was more significant(×10^-9:18.6±4.7 vs. 24.0±6.8,P〈0.01). Conclusion Danshen injection combined with conventional therapy can obviously down-regulate the FeNO content,alleviate the airway inflammation,effectively relieve the children recurrence of asthmatic bronchitis.
出处
《中国中西医结合急救杂志》
CAS
北大核心
2014年第6期439-441,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
河南省科技厅科技攻关项目(122102310144)
关键词
喘息性支气管炎
小儿
丹参注射液
呼出气一氧化氮
中西医结合疗法
Asthmatic bronchitis
Child
Danshen injection
Exhaled nitric oxide content
Integrative Chinese and western medicine treatment