女性泌尿生殖道支原体属感染及药敏分析

Mycoplasmacausing urogenital tract infections in female patients and drug susceptibility analysis

目的了解女性泌尿生殖道支原体属感染状况及药敏谱,指导临床合理使用抗菌药物。方法选择2008-2012年门诊就诊的10 756例疑似泌尿生殖道支原体属感染的女性患者进行宫颈分泌物支原体属培养及药敏试验,并采用SPSS 17.0进行统计分析。结果受检的10 756例患者中支原体属感染5 703例,阳性率为53.02%,其中解脲脲支原体(Uu)感染4 035例,阳性率为37.51%,人支原体(Mh)感染379例,阳性率为3.53%,Uu+Mh两者混合感染1 289例,阳性率为11.98%;Uu对克拉霉素、多西环素、四环素、交沙霉素、阿奇霉素、米诺环素敏感率>90.00%;2008-2012年历年各种抗菌药物对支原体属感染的敏感率和耐药率比较有不同程度差异。结论交沙霉素、多西环素、米诺环素、四环素可作为治疗女性泌尿生殖道支原体属感染的首选药物,临床治疗上应根据药敏试验的结果,合理选用抗菌药物。

OBJECTIVE To investigate the status of Mycoplasma infections in the urogenital tract of the female patients and drug susceptibility so as to guide the clinical reasonable use of antibiotics .METHODS The cervical se‐cretions from totally 10756 outpatients with suspected Mycoplasma infections in urinary tract from 2008 to 2012 were cultured for Mycoplasma ,the drug susceptibility testing was performed ,and the statistical analysis was car‐ried out with SPSS 17 .0 .RESULTS Of the 10756 patients investigated ,Mycoplasma infections occurred in 5703 cases with the positive rate of 53 .02% ,4035 cases with Ureaplasma urealyticum （Uu） infection accounted for 37 .51% ,379 cases with Mycoplasma hominis （Mh） infection accounted for 37 .51% ,and 1289 cases with the mixed infections of Uu＋Mh accounted for 11 .98% .The drug susceptibility rate of Uu to clarithromycin ,doxy‐cycline ,tetracycline ,josamycine ,azithromycin and minocycline were higher than 90 % .The drug susceptibility and resistance was different for diverse types of Mycoplasma infections over the years during 2008 - 2012 . CONCLUSION Josamycine ,doxycycline ,minocycline and tetracycline can be used as the first line antibiotics to treat Mycoplasma urogenital tract infections in female patients .Clinicians should reasonably choose antibiotics based on the drug susceptibility testing result .