血小板输注临床疗效与感染的相关性研究

Research on curative effect of platelet transfusion and its correlation with infection

目的探讨血小板输注的临床疗效及其与感染的相关性分析,为临床治疗提供依据和新思路。方法随机选取2011年3月-2013年9月176例血液病患者,根据出血状况与血小板计数等临床因素将患者分为预防组123例与治疗组53例,比较血小板输注前后、不同临床因素之间输注疗效的差异,采用SPSS18.0软件进行统计分析。结果患者的出血状况均得以明显改善,预防组输注血小板有效率为66.67%,显著高于治疗组的47.34%,差异有统计学意义(P<0.05);血小板输注有效率与血小板输注病因、输注次数、患者体质量、出血及感染等密切相关(P<0.05);多因素logistic回归分析显示,感染、输注次数及出血为影响血小板输注效果的独立危险因素。结论血小板输注后可显著改善患者的出血与凝血功能,效果、病因与次数、体质量与出血、感染等因素相关。

OBJECTIVE To study the clinical efficacy of platelet transfusion and its correlation with infection so as to provide reference and new thoughts for clinical treatment .METHODS Totally 176 cases of patients with blood diseases during Mar .2011 to Sep .2013 were selected randomly and divided into the preventive group （n=123） and the therapeutic group （n=53） according to the bleeding conditions and platelet counting .The curative effects before and after platelet transfusion were compared by different clinical factors .The software SPSS18 .0 was used for statistical analysis .RESULTS The bleeding condition of patients was obviously improved ,transfusion efficacy in the preventive group was 66 .67% ,significantly higher than that in the therapeutic group （47 .34% ） （ P〈0 .05） .The transfusion efficacy was closely related to causes for platelet transfusion ,transfusion times ,body mass of patient ,bleeding and infection （P〈0 .05） .The multi‐factor logistic regression analysis showed that infec‐tion , bleeding and transfusion times were the independent risk factors influencing transfusion efficacy . CONCLUSION Hemorrhage and clotting function were significantly improved after platelet transfusion .The effica‐cy of platelet transfusion is related to the transfusion causes and times ,body mass ,bleeding and infection .