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壳聚糖衍生物在生物黏附药物传输系统中的研究进展 被引量：2

Progress in Research of Chitosan Derivatives in Bioadhesive Drug Delivery System
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摘要 目的综述壳聚糖衍生物在生物黏附药物传输系统中的研究进展。方法对近年来国内外以壳聚糖衍生物作为生物黏附材料在药物传输系统中的研究进行总结和分析,介绍壳聚糖衍生物在生物黏附药物传输系统中的应用。结果与结论壳聚糖衍生物具有良好的理化性质,作为生物黏附材料能够显著延长制剂在黏膜的滞留时间,提高药物的相对生物利用度,是一类应用前景广阔的高分子黏附材料。 OBJECTIVE To review the applications and progress in research of chitosan derivatives in bioadhesive drug delivery system. METHODS The recent research of chitosan derivatives as mueoadhesive biomaterials in modern drug delivery systems was summarized and analyzed to explore the benefits and applications of these chitosan derivatives in bioadhesive drug delivery system. RESULTS AND CONCLUSION Chitosan derivatives are one of the most promising mucoadhesive polymers because of their good physicochemical properties, thus providing prolonged residence time and enhanced bioavailability.
作者 李昕阳 谢辉 严国俊
机构地区 南京中医药大学
出处 《中国药学杂志》 CAS CSCD 北大核心 2014年第23期2053-2057,共5页 Chinese Pharmaceutical Journal
基金 国家自然科学基金资助项目(81202922) 江苏高校优势学科建设工程资助项目
关键词 壳聚糖衍生物 生物黏附 药物传输系统 chitosan derivatives bioadhesion drug delivery system
分类号 R944 [医药卫生—药剂学]
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参考文献48

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二级参考文献22

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中国药学杂志
2014年 第23期

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