通心络胶囊联合前列地尔注射液对ACS患者PCI术后心血管事件的影响

Effect of Tongxinluo capsules combined with alprostadil injection on post-percutaneous coronary intervention cardiovascular events in patients with acute coronary syndrome

目的:观察通心络胶囊联合前列地尔注射液对冠心病PCI术后心血管事件的影响。方法:选择经皮腔内冠状动脉成形术(PTCA)支架植入术冠心病患者190例,随机分为3组。对照组予以正规冠心病二级预防治疗,前列地尔组在对照组基础上给予前列地尔注射液治疗,联合治疗组在前列地尔组治疗的基础上加服通心络胶囊。治疗结束后比较患者术后半年内的再发心绞痛、心源性猝死、再发心肌梗死、1年内支架内再狭窄等事件的发生情况。结果:与对照组相比,前列地尔组与联合治疗组能明显降低心绞痛复发率、心源性猝死率、心肌梗死再发率以及支架内再狭窄率,且联合治疗组作用明显优于单用前列地尔组,差异有统计学意义(P<0.05)。结论:通心络胶囊联合前列地尔能显著减少冠心病PCI术后1年内心血管事件的发生率及术后支架内再狭窄。

Objective： To observe the effect of Tongxinluo capsules combined with alprostadil injection on post-percutaneous coronary intervention（ PCI） cardiovascular events in patients with acute coronary syndrome. Methods： A total of 190 coronary heart disease（ CHD） patients undergoing percutaneous transluminal coronary angioplasty with stent implantation were randomly divided into control group,alprostadil group,and combination therapy group. The control group received secondary prevention of CHD; the alprostadil group was given alprostadil injection in addition to the therapy for the control group; the combination therapy group received Tongxinluo capsules in addition to the therapy for the alprostadil group. After treatment,the incidence of recurrent angina pectoris,sudden cardiac death,and recurrent myocardial infarction within0. 5 year after operation and the incidence of in-stent restenosis within 1year after operation were compared between the three groups. Results： Compared with the control group,the alprostadil group and combination therapy group had a significantly reduced incidence of recurrent angina pectoris,sudden cardiac death,recurrent myocardial infarction,and in-stent restenosis（ P〈0. 05）,and the combination therapy had significantly higher decreases in these indices than the alprostadil group（ P〈0. 05）. Conclusion： Tongxinluo capsules combined with alprostadil can significantly reduce the incidence of cardiovascular events and in-stent restenosis in CHD patients within 1 year after PCI.