温阳振衰颗粒对慢性充血性心力衰竭模型兔NT-proBNP、IL-1及IL-6的影响

Effects of Wenyang Zhenshuai granules on NT-pro BNP,IL-1,and IL-6 levels in rabbit model of chronic congestive heart failure

目的:观察温阳振衰颗粒对阿霉素诱导性慢性心衰模型兔NT-pro BNP、IL-1及IL-6的影响。方法:健康新西兰兔35只,随机抽取5只为正常对照组,余30只兔耳缘静脉注射阿霉素4周后,进行心功能测定,按心功能分层随机分为模型对照组,温阳低、中、高剂量组和阳性对照组,各组用对应药物灌胃治疗,连续4周。治疗结束后比较各组模型兔氨基末端脑钠尿肽前体(NT-pro BNP)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)水平的变化。结果:与模型对照组比较,各治疗组NT-pro BNP、IL-1、IL-6水平均降低(P<0.05),且温阳高剂量组疗效优于中、低剂量组。结论:温阳振衰颗粒能降低心衰模型兔NT-pro BNP、IL-1及IL-6的含量,其改善心功能的作用机制可能与抑制炎性细胞因子、减轻炎症反应有关。

Objective： To observe the effects of Wenyang Zhenshuai granules on N-terminal pro-brain natriuretic peptide（ NT-pro BNP）,interleukin-1（ IL-1）,and interleukin-6（ IL-6） levels in the rabbit model of chronic heart failure induced by adriamycin. Methods： Thirty-five healthy New Zealand rabbits were included in the study. Five rabbits were randomly selected from them as normal control group. The other 30 rabbits were given adriamycin injected into the auricular vein for 4 weeks and then underwent cardiac function test; stratified by the cardiac function,they were randomly divided into model control group,low-,medium-,and high-dose Wenyang Zhenshuai granule groups,and positive control group to receive respective treatments by gavage for 4 weeks. After treatment,these groups were compared in terms of the changes in NT-pro BNP,IL-1,and IL-6 levels. Results：Compared with the model control group,the low-,medium-,and high-dose Wenyang Zhenshuai granule groups had significantly reduced NT-pro BNP,IL-1,and IL-6 levels（ P 0. 05）,and the high-dose Wenyang Zhenshuai granule group had a better treatment outcome than the medium-and low-dose Wenyang Zhenshuai granule groups. Conclusion： Wenyang Zhenshuai granules can reduce the NT-pro BNP,IL-1,and IL-6 levels in the rabbit model of heart failure. Their action mechanism for improving cardiac function may involve inhibiting inflammatory cytokines and reducing inflammatory response.