尼可地尔治疗不稳定型心绞痛患者的临床疗效观察

Curative effect of nicorandilr on coronary heart disease patients with unstable angina pectoris

目的观察尼可地尔在冠心病不稳定型心绞痛患者中的临床疗效。方法选择2012年5月-2014年2月在海口市人民医院心内科住院确诊为不稳定型冠心病的162例患者,随机分为治疗组和对照组各81例,治疗组在对照组常规抗心绞痛药物治疗的基础上加用尼可地尔口服,观察两组的疗效。结果心绞痛改善治疗组总有效率为90.1%,对照组为72.8%,两组疗效比较,治疗组明显高于对照组（P〈0.05）。治疗组24h平均缺血时间及缺血次数均明显低于对照组（P〈0.05）。结论尼可地尔治疗不稳定性心绞痛安全有效。

Objective To observe the effect of nicorandil on coronary heart disease （CHD） patients with unstable anginapectoris of coronary heart disease. Methods The 162 CHD cases with unstable angina pectoris in Haikou MunicipalPeople＇s Hospital during May 2012- February 2014 were chosen and randomly divided into observation group and controlgroup each comprised 81 cases. All the patients in both groups were treated with conventional therapy and nicorandil wasadded to those in the observation group. The results of treatment in the two groups were evaluated.Results The total effectiverate in patients of the observation group was 90.1% and that in the control group was 72.8% revealing that the curative effect inthe patients of the observation group was significantly higher than that in control group （P 〈 0.05）.The average 24-hourischemia time and times of ischemia in the cases of observation group were significantly lower than that of the control group （P〈0.05）. Conclusion Nicorandil is safe and effective for treatment of CHD cases with unstable angina.