轻度认知障碍中西医发病机制的研究进展

Pathogenesis of mild cognitive impairment on Chinese medicine and Western medicine: review

轻度认知障碍(MCI)是介于正常衰老与痴呆之间的一种临界状态,属于痴呆的前期表现。中医认为,轻度认知障碍的发病机制,多是由于久病耗损、年迈体虚、七情内伤等病因,导致脏腑功能失调,气血津液输布失常,使脑失所养,或又夹杂风、火、痰、瘀、毒等病邪,致使脑脉痹阻,髓海失充,神机失用,脑窍失聪。西医关于MCI的发病机制,目前尚存在多种争议,其中分子生物学、血液流变学、影像学等越来越成为该病的热点研究领域。深入探索认知功能损伤机制对及早发现并治疗轻度认知障碍,预防老年痴呆具有一定的临床意义。

Mild cognitive impairment （MCI）, the early symptom of dementia, is a critical state between normal aging and dementia. In the theory of traditional Chinese Medicine （TCM）, pathogenesis of MCI was cerebral vessel obstruction, marrow sea underfill, mind disusing, and the brain orifice insensitive, mainly caused by several pathogenic factors such as prolonged illness, frail and seven abnormal emotions, which lead to dysfunctions of zang-fu organs and affect the distribution of qi-blood and body fluid, therefore making brain short of nutrition, or combined with comorbidity pathogenic factors such as wind, fire, phlegm, blood stasis and toxin and so on. Yet, there are many disputes on the pathogenesis of MCI in the theory of Western medicine. Hot research field of the disease covers molecular biology, blood rheology, imaging etc. Further exploration of its mechanism, early detection and treatment of cognitive impairment, and prevention Alzheimer＇s disease is of great clinical significance.