2型糖尿病患者血清心钠素浓度的变化及临床意义

Level of serum ANP in patients with type 2 diabetes mellitus and its clinical significance

目的 :观察2型糖尿病(type 2 diabetes mellitus,T2DM)与糖尿病前期(pre-diabetes,pre-DM)患者体内心钠素(atrial natriuretic peptide,ANP)的变化,探讨其在糖尿病发生发展中可能起的作用。方法 :共纳入84例研究对象,按血糖水平分为DM组、pre-DM组及正常对照组,应用ELISA法检测血清ANP水平。收集各组血糖、血脂等相关生化指标。结果:DM组ANP最低,其次是pre-DM组,均低于正常对照组,3组之间差异有统计学意义(P<0.05)。ANP与空腹血糖及餐后2 h血糖显著相关(P<0.01),与甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇不相关。结论 :ANP随着机体血糖的升高而逐渐降低,其在糖尿病发生发展中可能起重要作用。

Objective：To ivestigate the level of atrial natriuretic peptide（ANP） in patients newly diagnosed with type 2 diabetes mellitus（T2DM） and pre-diabetes（pre-DM）,and explore its role in the development of T2 DM. Methods：A total of 84 subjects enrolled was divided into 3 groups（DM group,pre-DM group and normal group） according to blood glucose. ELISA method was used to detect the serum ANP. Results：The level of ANP in the DM group was lowest,followed by that of pre-DM group,and both of them were lower than the ANP level of control group. There were significant differences among the three groups. Pearson correlation analysis showed that the level of ANP was negatively correlated with FBG and 2h PG（P〈0.01）, and was no correlation with TG,LDL-C and HDL-C. Conclusion：The serum ANP is lower with increased blood glucose,and may play a major role in the development of T2 DM.