α-硫辛酸通过降低氧化应激改善2型糖尿病低血糖脑病的研究

Investigation on the use of α-lipoic acid for ameliorate hypoglycemic encephalopathy in patients with type 2 diabetes by reducing oxidative stress

目的 :探讨抗氧化剂α-硫辛酸对2型糖尿病低血糖脑病氧化应激、内皮素-1和神经功能恢复的影响。方法 :将60例2型糖尿病低血糖脑病患者随机分为α-硫辛酸治疗组(30例)和对照组(30例),观察两组治疗前后氧化应激标志物丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)和内皮素-1(endothelin-1,ET-1)的变化,并比较两组治疗前后神经功能损害程度评分的不同。结果:α-硫辛酸组治疗后与治疗前相比较:MDA、ET-1以及神经功能损害程度评分均显著降低(分别为P<0.01、P<0.05、P<0.01),SOD显著增高(P<0.01)。对照组治疗后与治疗前相比较:MDA与神经功能损害程度评分显著降低(分别为P<0.05、P<0.01)。α-硫辛酸组与对照组治疗后相比较,MDA、ET-1及神经功能损害程度评分显著降低(分别为P<0.05、P<0.05、P<0.01),SOD显著增高(P<0.05)。结论:α-硫辛酸可改善氧化应激及内皮功能,有助于2型糖尿病低血糖脑病的恢复。

Objective：To investigate influence of antioxidant α-lipoic acid on oxidative stress, endothelin-1 and recovery of neuronal function in type 2 diabetic patients with hypoglycemic encephalopathy. Methods：A total of 60 type 2 diabetic patients with hypoglycemic encephalopathy were randomly divided to control group（n=30） and α-lipoic acid treatment group（n=30）. The differences in malondialdehyde（MDA）, superoxide dismutase（SOD） and endothelin-1（ET-1） were observed between the control group and the α-lipoic acid treatment group before and after treatment. Neurological impairment score was compared between the two groups. Results：The levels of MDA and ET-1 as well as the neurological impairment score were significantly decreased after α-lipoic acid treatment（P〈0.01, P〈0.05 and P〈0.01, respectively）, whereas the level of SOD was significantly increased afte r α-lipoic acid treatment（P〈0.01）. The levels of MDA and the neurological impairment score were significantly decreased in the control group after treatment（P〈0.05 and P〈0.01, respectively）. Furthermore, there were significant decreases in the levels of MDA And ET-1,neurological impairment score（P〈0.05, P〈0.05 and P〈0.01, respectively）, and the level of SOD（P〈0.05） in the α-lipoic acid group compared to the control group after treatment. Conclusion：α-lipoic acid can ameliorate hypoglycemic encephalopathy in type 2diabetic patients by reducing oxidative stress and improving endothelial function.