调节性T淋巴细胞在恶性胸腔积液发病机制中作用的研究进展

Regulatory T cells in the pathogenesis of malignant pleural effusion

恶性胸腔积液由恶性肿瘤胸膜转移或恶性胸膜间皮瘤引起,预后极差,肿瘤细胞浸润到胸膜腔可能同时受到肿瘤细胞特性和肺癌患者宿主因素的影响。恶性胸腔积液中有淋巴细胞聚集,CD4+CD25+调节性T淋巴细胞(Treg)增多,Treg细胞属于"职业抑制性T细胞",该文就Treg细胞的研究近况及其在恶性胸腔积液发病机制中的作用综述如下。

Malignant pleural effusion which carries a poor prognosis is frequently observed in malignant pleu -ral metastasis or malignant pleural mesothelioma .The factors that recruit tumor cells into pleural cavity are involved in both tumor cells characteristics and hosts .In malignant pleural effusion lymphocytes are dominant , and regulatory T cells are upregulated.Regulatory T cell（Treg） is a unique CD4＋CD25＋T cell population of “professional” regu-latory/suppressor T cells that actively and dominantly prevent both the activation and the function of autoactive T cells that have escaped other mechanisms of tolerance .This paper reviewed the research progress in regulatory T cells and its role in the pathogenesis of malignant pleural effusion .