URG11在前列腺癌组织中的表达及临床意义

Expression and significance of up-regulated gene 11 in prostate cancer

目的 探讨URG11基因在前列腺癌组织中的表达及临床意义.方法 68例前列腺癌患者临床资料和组织标本,采用免疫组织化学方法观察URG11在前列腺癌组织和良性前列腺增生组织中的表达.结果 前列腺癌组织URG11阳性率为70.6％;对照组阳性率为21.6％,两组比较差异有统计学意义（x2=34.32,Pp＜0.01）.URG11在前列腺癌组织的表达强度与Gleason评分、TNM分期呈正相关（r=0.354、0.740,P＜0.05）,而与患者年龄无明显相关（P＞0.05）.结论 URG1 1在前列腺癌组织中高表达,与前列腺肿瘤的发生、发展密切相关.

Objective To study the expression and clinical significance of up-regulated gene 11 （URG11） in prostate cancer.Methods Sixty-eight patients diagnosed as prostate cancer from June 2010 to June 2013 at the First Affliated Hospital of Ji＇ nan University were retrospectively.The expression of URG11 was detected by immunohistochemistry in prostate cancer and benign prostatic hyperplasia tissues.Results The positive expression rate of UGR11 in prostate cancer and benign prostatic hyperplasia tissues was 70.6% and 21.6% respectively （x2 =34.32,P 〈0.01）.The expression of UGR11 in prostate cancer was significantly correlated with the pathological grading system （Gleason grading system） and TNM staging （r =0.354,0.740,P 〈 0.05）,but not with age （P 〉 0.05）.Conclusion The increased expression of UGR1 1 in prostate cancer is closely correlated with pathogenesis of prostate cancer.