脂联素及其受体在肝细胞性肝癌组织中的表达

Expression of adiponectin and its receptors in human hepatocellular carcinoma tissues

目的 探讨脂联素及其受体——脂联素受体1（AdipoR1）、脂联素受体2（AdipoR2）和T-钙黏蛋白（T-cadherin）的表达与肝细胞性肝癌（HCC）临床病理特征的关系.方法 免疫组织化学法检测脂联素及其受体在42例HCC交界组织（含癌组织及癌旁组织）的表达.结果 脂联素（2.88±1.06比5.98 ±0.95）、AdipoR1（2.36±1.38比5.43±1.04）、AdipoR2（2.29±1.55比5.14±1.22）及T-cadherin（2.17±1.34比5.21±1.18）在HCC癌组织中的表达低于癌旁组织,且在伴有癌栓的癌组织中表达亦显著降低.脂联素（2.30±1.16比3.06 ±0.98）、AdipoR2（1.20±1.48比2.63±1.43）在伴卫星灶的癌组织表达低于不伴卫星灶的癌组织;直径＞5 cm的癌组织中T-cadherin表达（1.59±1.33）低于直径≤5 cm的癌组织（2.56±1.23）.结论 脂联素及其受体表达下调可能在HCC肝内转移过程中起一定作用.

Objective To investigate the relationship among adiponectin,its receptors （AdipoR1,AdipoR2 and T-cadherin） and the pathological characteristics of human hepatocellular carcinoma （HCC）.Methods The expression of Adiponectin,AdipoRl,AdipoR2 and T-cadherin was detected by immunohistochemistry in 42 cases of HCC tissues （tumor hepatic tissues and pericarcinomatous tissues）.Results The expression of Adiponectin （2.88 ± 1.06 vs.5.98 ± 0.95）,AdipoR1 （2.36 ± 1.38 vs.5.43 ±1.04）,AdipoR2 （2.29±1.55 vs.5.14±1.22） andT-cadherin （2.17±1.34 vs.5.21 ±1.18） was decreased in tumor hepatic tissues compared to pericarcinomatous tissues.The expression of Adiponectin （2.57±1.03 vs.3.19±1.03）,AdipoR1 （1.81 ±1.44 vs.2.90±1.09）,AdipoR2 （1.48±1.47 vs.3.10 ± 1.18） and T-cadherin （1.76 ± 1.34 vs.2.57 ± 1.25） in HCC tissues with tumor thrombi was lower than in cancerous tissues without tumor thrombi.Adiponectin （2.30 ± 1.16 vs.3.06 ±0.98） and AdipoR2 （1.20 ± 1.48 vs.2.63 ± 1.43） expression in HCC tissues with satellite lesions was lower than in cancerous tissues without satellite lesions.The expression of T-cadherin in large size （〉5 cm） tumor tissues （1.59 ± 1.33） was lower than in the small size （≤5 cm） tumor tissues （2.56 ± 1.23）.Conclusion The decreased expression of Adiponectin and its receptors may play a role in the intrahepatic metastasis of HCC.