左卡尼汀联合厄贝沙坦治疗高血压肾病的疗效观察

Curative effect observation of levocarnitine combined with irbesartan in the treatment of hypertensive nephropathy

目的：观察左卡尼汀联合厄贝沙坦治疗高血压肾病的临床疗效。方法80例高血压肾病患者随机分为两组：A组口服厄贝沙坦75~150 mg/d；B组联合使用左卡尼汀和厄贝沙坦治疗,左卡尼汀3.0 mg/d静脉滴注,厄贝沙坦75~150 mg/d,疗程均为14 d。观察治疗前后两组患者血压和肾功能变化及不良反应。结果与治疗前比较,两组患者血压和24 h尿蛋白定量均明显降低（P〈0.01）；两组比较, B组降低更为显著（P〈0.01）。两组均未发生严重不良反应。结论左卡尼汀联合厄贝沙坦治疗高血压肾病可有效控制血压,降低24 h尿蛋白,疗效及安全性好。

Objective To observe the clinical effect of levocarnitine combined with irbesartan in the treatment of hypertensive nephropathy. Methods A total of 80 cases with hypertensive nephropathy were randomly divided into two groups. Group A took oral administration of 75~150 mg/d of irbesartan, and group B received combination treatment through intravenous infusion of 3.0 mg/d of levocarnitine and 75~150 mg/d of irbesartan. After 14 d of treatment, the changes of blood pressure, renal function before and after treatment, and adverse reactions were observed in the two groups. Results Compared with the levels before treatment, the levels of blood pressure and 24 h urinary protein were significantly decreased after treatment （P〈0.01）. The decrease in group B was more remarkable than in group A （P〈0.01）. There were no severe adverse reactions in the two groups. Conclusion Levocarnitine combined with irbesartan in the treatment of hypertensive nephropathy can effectively control blood pressure and reduce 24h urinary protein. It has good curative effect and safety.