滋阴清热方对气道高反应性咳嗽患者IL-4、IFN-γ的影响

Effects of Ziyinqingre formula on IL-4 and IFN-γ in patients with bronchial hyper-responsive cough

目的探讨滋阴清热方对气道高反应性咳嗽患者外周血白介素-4(IL-4)、干扰素-γ(IFN-γ)的影响。方法将明确诊断为气道高反应性咳嗽的患者64例,随机分为对照组和治疗组各32例,治疗组给予滋阴清热方治疗,对照组给予孟鲁司特钠片治疗。疗程均为14天。观察患者治疗前后咳嗽症状积分以及外周血IL-4、IFN-γ的变化。结果治疗后,治疗组患者咳嗽症状减轻程度优于对照组(P<0.05);治疗组总有效率(84.4%)高于对照组(71.9%),2组比较差异有统计学意义(P<0.05)。治疗组IL-4下降及IFN-γ升高均较对照组明显(P<0.05)。结论滋阴清热方治疗气道高反应性咳嗽的作用机制可能与降低血中IL-4水平,提高IFN-γ水平,维持Th1/Th2细胞的平衡,从而减轻气道炎症有关。

Objective To explore the effects of Ziyinqingre formula on IL-4 and IFN-γ in patients with bronchial hyper-responsive cough. Methods Sixty-four patients of bronchial hyper-responsive cough were randomly divided into a control group and a TCM group,32 cases in each one. The TCM group was treated with Ziyinqingre formula,while the control group was treated with montelukast sodium tablets. The treatment was given for 2 weeks in two groups. The cough symptom score and level of IL-4 and IFN-γ were observed before and after treatment in two groups. Results After the treatment,the symptoms improvement of cough in the TCM group was superior to that in the control group（ P〈0. 05）. The total effective rate was 84. 4% in the TCM group,which was superior to 71. 9%in the control group（ P〈0. 05）. The reducing of IL-4 and increasing of IFN-γ in the TCM group were more significant than those in the control group（ P〈0. 05）. Conclusion Ziyinqingre formula has superior clinical efficacy on bronchial hyper-responsive cough,which may be related with reducing the level of IL-4,increasing level of IFN-γ,maintaining the balance of Th1 / Th2 cells,and relieving the airway inflammation.