低剂量葛根素注射液治疗糖尿病并发冠心病心绞痛临床观察

The clinical observation of low dose puerarin injection on the treatment of diabetes mellitus complicated with angina pectoris of coronary heart disease

目的观察低剂量葛根素注射液治疗2型糖尿病并冠心病心绞痛的临床疗效。方法将58例确诊2型糖尿病并发冠心病心绞痛的患者随机分为治疗组30例和对照组28例。治疗组除常规治疗外,加用低剂量葛根素注射液静脉滴注,对照组给予常规用药。观察2组临床症状、心电图、血脂等指标,并选择部分条件较好的患者(治疗组13例,对照组10例)进行用药前后活动平板试验。结果在心绞痛症状缓解方面,治疗组总有效率高于对照组(P<0.05);在心电图缺血情况改善方面,治疗组的总有效率优于对照组(P<0.05);治疗后2组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)均低于治疗前,高密度脂蛋白胆固醇(HDL-C)均高于治疗前,差异均有统计学意义(P<0.05);治疗组活动平板试验各项指标改善程度较对照组显著(P<0.05)。结论低剂量葛根素注射液治疗2型糖尿病并发冠心病心绞痛安全可靠,疗效确切。

Objective To observe the clinical curative effect of low dose puerarin injection on the treatment of angina pectoris of coronary heart disease complicated with type 2 diabetes mellitus.Methods 58 cases patients with type 2 diabetes mellitus complicated with angina pectoris of coronary heart disease were randomly divided into treatment group（30 cases）and control group（28 cases）.Except of routine treatment,treatment group was given low dose puerarin injection.Control group was given routine treatment.Observed the clinical symptoms,electrocardiogram and blood lipid.Some patients with better conditions did the treadmil test.Results The treatment group was superior to the control group in improving the clinical symptoms,elec-trocardiogram,blood lipid and treadmill test,the differences were statistically significant（P〈0.05）.Conclusion Low dose Puerarin injection in treatment of type 2 diabetes mellitus complicated with angina pectoris of coronary heart disease is safe and reliable,and has curative effect.