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散发性结直肠癌遗传标识物研究进展 被引量：6

Advances in Genetic Markers of Sporadic Colorectal Cancer
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摘要 散发性结直肠癌(sporadic colorectal cancer,sCRC)是一类没有明显家族遗传倾向,由遗传因素和环境因素共同作用的消化道恶性肿瘤。近年来,分子技术的发展使发现复杂疾病潜在的生物标识物成为可能。基于全基因组关联研究(genome-wideassociationstudy,GWAS)以及高通量测序技术的应用,已经从全基因组范围内确定了大量肿瘤易感基因以及其后天突变标识物。本文对近年来散发性结直肠癌(sCRC)遗传标识物最新研究进展作一综述,并对其未来研究方向加以展望。 Sporadic colorectal cancer （sporadic colorectal cancer, sCRC） is a kind of gastrointestinal malignancies with no obvious familial tendency, caused by both genetic and environmental fa：tors. In recent years, the developmerit of molecular techniques make it possible discover the potential biological markers of complex trait. Based on genome-wide association studies （genome-wide association study, GWAS） and the application of high-throughput sequencing technology, research has identified a large number of cancer susceptibility genes and somatic mutations genome-widely. In this paper, we summarize the latest research progress of sCRC genetic markers and make prospects for its futuristic research directions.
作者 郑万里 陈尔飞 杨进
机构地区 西北大学生命科学学院预防基因组医学研究所
出处 《基因组学与应用生物学》 CAS CSCD 北大核心 2014年第4期924-929,共6页 Genomics and Applied Biology
基金 948项目(2010-G2-01) 国家国际科技合作专项项目(2011DFB31690)共同资助
关键词 散发性结直肠癌 遗传基础 遗传标识物 全基因组关联研究 高通量测序 Sporadic colorectal cancer, Genetic basis, Genetic markers, Genome-wide association studies, High-throughput sequencing
分类号 R735.34 [医药卫生—肿瘤]
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参考文献31

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基因组学与应用生物学
2014年 第4期

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