尤瑞克林对脑梗死患者疗效及血清hs-CRP和PCT的影响

The effect of human urinary kallidinogenase on patients with cerebral infarction and expressions of hs-CRP and PCT

目的探讨尤瑞克林治疗脑梗死患者的效果及对血清超敏C反应蛋白(hs-CRP)和降钙素原(PCT)的影响。方法收集脑梗死患者140例,随机分为2组,每组70例。对照组应用常规方法治疗(银杏达莫+氯吡咯雷+拜阿司匹林),观察组在常规治疗基础上加用尤瑞克林治疗,共治疗14 d。于治疗前、后对患者血清中hs-CRP和PCT的水平进行检测,计算脑梗死体积变化,并比较美国国立研究卫生院卒中量表评分(NIHSS)。结果治疗14 d后,2组脑梗死体积、NIHSS评分均下降(P<0.05),且观察组梗死灶体积下降和NIHSS评分下降明显优于对照组(P<0.05)。治疗后2组血清hs-CRP、PCT均下降(P<0.05),且观察组下降值明显高于对照组(P<0.05)。结论尤瑞克林对脑梗死的治疗效果理想,同时能有效地降低血清hs-CRP和PCT的表达,临床中可以推广应用。

Objcet ive To investigate the effect of human urinary kallidinogenase on treatment in patients with cere -bral infarction and expression of serum high sensitivity C reactive protein （hs-CRP） and procalcitonin （PCT．Methods 140 cases of patients with cerebral infarction were enrolled , they were randomly divided into 2 groups, 70 cases in each grou．The control group was given conventional treatment （ ginkgo leaf extract and dipyridamole ＋clopidogrel ＋aspirin） , the observa-tion group besides the conventional treatment , combined with human urinary kallidinogenase , a total of 14 d treatment were complete．Before treatment and after treatment , the expression of hs-CRP and PCT of patients with cerebral infarction were detected, cerebral volume were measured, and compared the United States National Institutes of Health Stroke Scale （NIHSS） scor．Results After 14 d’s treatment, 2 groups of cerebral infarction volume were decreased （ P ＜0．05）, NIHSS score were decreased （ P ＜0．05）, and the observation group’s infarct volume decrease and NIHSS score were better than that of control group （ P ＜0．05．After treatment, the 2 groups’ hs-CRP and PCT were decreased （ P＜0．05）, and the observa-tion group decreased significantly than that in the control group （ P ＜0．05．Conclusion The effect of human urinary kal-lidinogenase on patients with cerebral infarction is good , and can effectively reduce the expression of hs-CRP and PCT, it is worthy be applied in clinical treatment．