瘢痕疙瘩的细胞信号转导通路的研究进展

Research Progress of Cell Signal Transduction Pathway in Keloids

瘢痕疙瘩(Keloids,KD)是一种继发于创伤的结缔组织过度增生性皮肤病,易感人群好发,通常不会自发消退,手术切除后极易复发,是目前整形外科亟待解决的临床难题。KD的发病机制十分复杂,是多种因素共同作用的结果,如细胞因子、细胞信号传导通路、胶原代谢、基因表达和细胞的增殖与凋亡等。本文对近几年有关KD细胞信号传导通路和特异性蛋白的研究进展进行综述。

Keloids, secondary to trauma, is a kind of skin disease with excessive connective tissue hyperplasia. It often happens in susceptible population. Spontaneous regression is considered to be extremely unlikely and it is easy to relapse after surgical resection. It is currently a challenging clinical problem of plastic surgery. The pathogenesis of KD is complex. It is the result of joint action of many factors, such as cytokine, cell signal transduction pathway, collagen metabolism, gene expression, cell proliferation and apoptosis, etc. In this paper, the cell signal transduction pathways and specific proteins related to KD were reviewed.