摘要
Phytochemical investigation of the leaves of Ilex aspralla （Hook. et Am.） Champ. ex Benth. led to the isolation of eleven compounds （1-11）. By comparison with those reported data in the literatures their structures were identified as kaempferol-3-O-β-D- 6＂-acetylglucopyranoside （1）, kaempferol-4＇-methylether （2）, quercetin （3）, quercetin-3-O-glucopyranoside （4）, tormentoside （5）, suavissimoside R1 （6）, 3β,19α-dihydroxyolean-12-ene-24,28-dioicacid-28-O-β-D-glucopyranoside （7）, 3-O-β-sulfooxy-19-hydroxy- urs-12-ene-28-oic acid （8）, coniferin （9）, adenoside （10）, 1＇-O-benzyl-ct-L-rhamnopyranosyl-（l＂→6＇）-β-D-glucopyranoside （11）. Among these, six compounds （1, 2, 5, 9-11） were firstly reported from the genus Ilex, and five compounds （3, 4, 6-8） were isolated for the first time from llex aspralla.
研究冬青属植物岗梅叶的化学成分,通过硅胶柱色谱、Sephadex LH-20柱色谱、反相硅胶柱色谱、制备高效液相色谱等色谱方法分离纯化得到11个化合物,经多种波谱方法鉴定及与文献对照,其结构分别为kaempferol-3-O-β-D-6′′-acetylglucopyranoside(1),kaempferol-4'-methylether(2),quercetin(3),quercetin-3-O-glucopyranoside(4),tormentoside(5),suavissimoside R1(6),3β,19α-dihydroxyolean-12-ene-24,28-dioicacid-28-O-β-D-glucopyranoside(7),3-O-β-sulfooxy-19-hydroxyurs-12-ene-28-oic acid(8),coniferin(9),adenoside(10),1′-O-benzyl-α-L-rhamnopyranosyl-(1′′→6′)-β-D-glucopyranoside(11)。其中化合物1,2,5,9–11为首次从冬青属植物中分离得到,化合物3,4,6–8为首次从岗梅叶中分离得到。
基金
National Key Technology R&D Program "New Drug Innovation" of China (Grant No.2012ZX09201-201-001,2012ZX09301002-002-002 and 2012ZX09304-005)
Doctoral Fund of Ministry of Education (Grant No.20110001130003)
