轮状病毒在婴幼儿腹泻中检测的临床意义

Clinical significance of rotavirus detection in infantile diarrhea

目的：了解广州地区婴幼儿腹泻轮状病毒（RV）的感染情况,为临床诊断和治疗提供可靠的实验数据。方法：收集该院2010年1月~2011年12月住院和门诊的腹泻婴幼儿粪便标本1 437例,采用免疫层析双抗体夹心法进行A组RV抗原检测,并比较分析检测数据。结果：患儿年龄（1.44±1.09）岁,有497例检测结果阳性,阳性率34.59%;其中0.5~1岁组阳性率可达39.81%（构成比66.00%）,0.5~3岁组为高发年龄（构成比为89.54%）。每年秋冬季节10~12月份为发病高峰（构成比79.88%）;2010年和2011年RV总阳性率一致。结论：RV是该地区婴幼儿腹泻（0~5岁）的主要病原,0.5~3岁婴幼儿是RV的易感人群,秋冬季节10~12月份为发病高峰。

Objective： To understand rotavirus infection status of infants in Guangzhou,provide reliable experimental data for clinical diagnosis and treatment. Methods： The stool specimens of 1 437 infants with diarrhea were collected from outpatient department and inpatient department of this hospital from January 2010 to December 2011,immunochromatography and double antibody sandwich method were used to detect group A rotavirus antigen; then the data was compared and analyzed. Results： The age of infants was（ 1. 44 ± 1. 09） years old; 497 infants were found with positive rotavirus,the positive rate was 34. 59%; the positive rate in 0. 5-1-year-old group was39. 81%,the proportion was 66. 00%; the peak age was 0. 5-3 years old,the proportion was 89. 54%. Rotavirus infection mainly occurred from October to December,the proportion was 79. 88%; the total positive rates of rotavirus in 2010 and 2011 were consistent. Conclusion：Rotavirus is the major pathogen of diarrhea in infants aged 0-5 years old in Guangzhou,the infants aged 0. 5-3 years old are susceptible to rotavirus infection,rotavirus infection mainly occurs from October to December.