中国可疑血流感染新生儿行血培养阳性率的系统评价和Meta分析

Blood culture positive rate of neonates suspected of bloodstream infection in China:a systematical review and Meta analysis

目的：了解我国可疑血流感染新生儿行血培养阳性率情况及影响因素。方法：系统检索《中国生物医学文献数据库》（CBM）、《中国期刊全文数据库》（CNKI）、《中国科技期刊数据库》（VIP）收录的＂核心期刊＂中1990~2014年3月发表的文献及检索Pub Med（1966~2014年3月）中的文献,选择报告了我国新生儿血培养阳性率的无对照观察性研究,摘录有关信息,使用R3.0.3中Meta分析包对各资料间进行异质性检验,以确定采用固定模型或随机模型进行合并分析。结果：共纳入16篇文献,中国新生儿可疑血流感染行加权合并的血培养阳性率为14%（95%CI：10%~19%）。结论：我国可疑血流感染行血培养阳性率不高,需进一步规范血培养标本采集、送检等流程。

Objective： To understand the blood culture positive rate of neonates suspected of bloodstream infection in China and the influencing factors. Methods： The literature published from 1990 to March 2014 and included by CBM,CNKI and CSTJ and the literature published from 1966 to March 2014 included by Pub Med were retrieved systematically,the observational studies without control group reporting blood culture positive rate in neonates in China were selected,the related information was extracted; heterogeneity test was performed by Meta analysis on R3. 0. 3 software,the data was merged and analyzed by fixed model or random model. Results： A total of 16 studies were included for this analysis. The weighted blood culture positive rate of neonates suspected of bloodstream infection in China was14%（ 95% CI： 10%-19%）. Conclusion： Blood culture positive rate of neonates suspected of bloodstream infection in China is at a low level,blood culture specimen collection and inspection should be further standardized.