评估卡前列素氨丁三醇预防孕产妇剖宫产术中及术后出血的效果

An Evaluation of the Effect of Romethamine on the Bleeding Prevention in Cesarean Section

目的评估应用卡前列素氨丁三醇对存在出血高危因素的孕产妇在剖宫产术中、术后止血的作用及不良反应的发生情况。方法将广州市某医院存在出血高危因素的孕产妇于剖宫产术后随机分为2组。对照组134例,术中在宫体局部注射缩宫素20IU,另外静脉滴注缩宫素20IU;观察组123例,术中在宫体局部注射缩宫素20IU以及卡前列素氨丁三醇250μg。计算术中、术后2h及24h出血量,并观察患者不良反应的发生情况。结果观察组孕产妇术中、术后2h以及24h的出血量均较对照组减少,差异有统计学意义(P<0.05)。2组孕产妇用药以后呕吐、腹泻、发热等不良反应的发生率比较差异有统计学意义(P<0.05)。结论对于存在出血高危因素的孕产妇在进行剖宫产术后加用卡前列素氨丁三醇,可显著减少术中及术后的出血量,无严重不良反应,效果良好。

Objective To evaluate the effect of romethamine on the intra-operative and post-operative hemostasis in cesarean section for women with high risk of maternal hemorrhage and observe the incidence of adverse reactions.Method Pregnant women with high risk of hemorrhage for cesarean section in our hospital were randomly divided into a control group with 134 cases and an observation group with 123 cases.Patients in the control group had palace local injection of oxytocin 20 IU and intravenous infusion of oxytocin 20 IU in the operation and those the observation group had palace local injection of oxytocin 20 IU and romethamine 250μg to calculate the amount of bleeding in the operation,2hand 24 hafter the cesarean section and to observe the incidence of adverse reactions in patients.Results In the observation group,the amount of bleeding in the operation,2hand 24 hafter the cesarean section was lower than the control group and the difference was statistically significant（P〈0.05）.There were statistically significant differences（P〈0.05）in the incidence of adverse reactions like vomiting,diarrhea,fever,etc after maternal treatment between the two groups.Conclusion The application of romethamine for women with high risk of maternal hemorrhage during cesarean section can significantly reduce the amount of bleeding during and after the operation with good effect and no serious adverse reactions.