序贯疗法与标准三联疗法治疗幽门螺杆菌的临床疗效比较

Comparison of clinical therapeutic effect of sequential therapy and standard triple therapy for Helicobacter pylori

目的：研究序贯疗法与标准三联疗法治疗幽门螺杆菌的临床疗效。方法选取幽门螺杆菌阳性患者120例，按照数字表法将患者分为A组和B组，每组60例。 A组给予序贯疗法（奥美拉唑＋阿莫西林治疗5 d以后继续以奥美拉唑＋克拉霉素＋替硝唑治疗5 d）治疗，B组给予标准三联疗法（奥美拉唑＋阿莫西林＋克拉霉素）治疗，比较两组幽门螺杆菌根除率、溃疡愈合总有效率以及不良反应。结果 A组幽门螺杆菌的根除率91．7％（55／60），显著高于对照组的71．7％（43／60）（χ^2＝11．915，P＝0．023）；A组溃疡愈合总有效率96．7％（58／60），显著高于B组的88．3％（53／60）（χ^2＝9．915，P＝0．038）；两组不良反应发生率差异无统计学意义（χ^2＝4．735，P＝0．072）。结论序贯疗法相比标准三联疗法治疗幽门螺杆菌具有较好的效果，能显著提高幽门螺杆菌的根除率，且无严重不良反应。

Objective To study the clinical effects of sequential therapy and standard triple therapy for Helicobacter pylori.Methods 120 cases with positive Helicobacter pylori were divided into A group and B group according to the number table method,60 cases in each group.A group received sequential therapy （ omeprazole＋amoxicillin treatment after 5 days continue to omeprazole clarithromycin and metronidazole treatment for 5 days）,B group received standard triple therapy （ omeprazole ＋amoxicillin ＋clarithromycin ） , eradication rate of Helicobacter pylori,the total efficiency of ulcer healing and adverse reaction of the two groups were compared.Results The eradication rate of Helicobacter pylori of group A was 91.7%（55/60）,which was significantly higher than 71.7%（43/60） of group B （χ^2 =11.915,P=0.023）;the ulcer healing and the total effective rate of group A was 96.7%（58/60）,which was significantly higher than 88.3%（53/60） of group B,the difference was statistically significant （χ^2 =9.915,P=0.038）;there was no statistically significant difference between the two groups in adverse reaction （χ^2 =4.735,P=0.072）.Conclusion Sequential therapy has a better effect in treatment Helicobacter pylori than the standard triple therapy, which can significantly improve the eradication of Helicobacter pylori, with no serious adverse reactions.