参松养心胶囊联合硝酸甘油治疗稳定型心绞痛的临床观察

Clinical Observation of Shensong Yangxin Capsule Combined with Nitroglycerin in the Treatment of Stable Angina Pectoris

目的：观察参松养心胶囊联合硝酸甘油治疗稳定型心绞痛的临床疗效和安全性。方法：将128例稳定型心绞痛患者随机均分为观察组和对照组。两组患者均给予血小板抑制剂、转化酶抑制剂、调脂药、B受体阻滞药和／或钙拮抗药等常规治疗。在此基础上，对照组患者给予硝酸甘油注射液10mg加入5％葡萄糖溶液250ml中，以10-20μg／min速度静脉滴注4～6h，每日1次；观察组患者在对照组治疗的基础上给予参松养心胶囊4粒，口服，每日3次。两组患者疗程均为2周。观察两组患者的临床疗效，治疗前后心绞痛发作次数、运动诱发心绞痛时间、ST段下降1mm所需时间、运动持续时间、心率×收缩压、血液流变学指标、血脂指标[总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）1及不良反应发生情况。结果：治疗后观察组患者总有效率显著高于对照组，两组比较差异有统计学意义（P〈0．05）。治疗前两组患者心绞痛发作次数，运动诱发心绞痛时间，ST段下降1mm所需时间，运动持续时间、心率×收缩压、血液流变学指标、血脂指标比较，差异均无统计学意义（P〉0．05）；治疗后两组患者心绞痛发作次数、心率×收缩压、血液流变学指标、TG、TC、LDL均显著低于同组治疗前，且观察组低于对照组，而运动诱发心绞痛时间、ST段下降1mm所需时间、运动持续时间、HDL均显著高于同组治疗前，且观察组高于对照组，差异均有统计学意义（P〈0．05）。两组患者治疗期间均未见严重不良反应发生。结论：参松养心胶囊联合硝酸甘油治疗稳定型心绞痛较单用硝酸甘油疗效更显著，安全性相似。

OBJECTIVE：To observe clinical efficacy and safety of Shensong yangxin capsule combined with nitroglycerin in the treatment of stable angina pectoris. METHODS：128 patients with stable angina pectoris were randomly divided into control group and observation group. 2 groups were given Platelet inhibitors,Converting enzyme inhibitor,Lipid-regulating agent,β receptor blocker and/or calcium antagonist. Control group was additionally given Nitroglycerin injection 10 mg added into 250 ml of 5%Glucose solution,with intravenous drip speed of 10-20 ug/min,for 4-6 h,once a day,for consecutive 2 weeks. Observation group was additionally given Shensong yangxin capsule 4 pills orally,3 times a day,one the basis of control group. Treatment course of2 groups lasted for 2 weeks. Clinical efficacies of 2 groups were observed,and the frequency of angina pectoris attack,duration of exercise-induced angina pectoris,the time of ST segment descending 1 mm,duration of exercise,heart rate × systolic pressure,blood rheological parameters,blood lipid index [TC,TG,LDL,HDL] and the occurrence of ADR were observed before and after the treatment. RESULTS：Total effective rate of observation group was significantly higher than in control group;there was statistical significance（P〈0.05）. There was no statistical significance in the frequency of angina pectoris attack,duration of exercise-induced angina pectoris,the time of ST segment descending 1 mm,duration of exercise,heart rate×systolic pressure,blood rheological parameters,blood lipid index between 2 groups before treatment（P〉0.05）. The frequency of angina pectoris attack,heart rate×systolic pressure,blood rheological parameters,TG,TC and LDL of 2 groups after treatment were lower than before,and the observation group was lower than the control group;the duration of exercise-induced angina pectoris,the time of ST segment descending 1 mm,duration of exercise and HDL of 2 groups after treatment were higher than before,and the observation group was higher than the control group;there was statistical significance（P〈0.05）. No severe ADR was found in 2 groups during treatment.CONCLUSIONS：Shensong yangxin capsule combined with nitroglycerin is effective and safe for stable angina pectoris.