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老年肥胖和骨质疏松 被引量:5

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摘要 传统观念认为,超重和肥胖对骨具有保护作用,有利于抗骨质疏松,而低体质量则是骨量减少的危险因素。肥胖者骨密度(BMD)比较高的原因包括:骨骼承受的机械负荷一方面通过Wnt/β-catenin信号通路,促进成骨细胞增殖分化,从而刺激成骨;另一方面通过调节核因子-κB(NF-κB)受体激活物配基(RANKL)/护骨素(OPG)系统,抑制破骨细胞分化,从而减少骨吸收。
作者 贾红蔚 朱梅
出处 《实用老年医学》 CAS 2014年第11期887-890,共4页 Practical Geriatrics
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  • 1Villareal DT, Apovian CM, Kushner RF, et al. Obesity in older adults: technical review and positionstatement of the American Society for Nutrition and NAASO, The Obesity Society[ J ]. Am J Clin Nutr, 2005, 82(5) :923-934.
  • 2Bonewald LF, Johnson ML. Osteo- cytes, mechanosensing and Wnt sig- naling[J]. Bone, 2008, 42(4): 606-615.
  • 3Li J, Wan Z, Liu H, et al. Osteo- blasts subjected to mechanical strain inhibit osteoclastic differentiation and bone resorption in a co-culture system[J].Ann Biomed Eng, 2013, 41 (10) :2056-2066.
  • 4Kim JH, Choi HJ, Kim M J, et al. Fat mass is negatively associated with bone mineral content in Koreans [ J ]. Osteoporosis Int, 2012, 23 (7) : 2009-2016.
  • 5Vincent HK, Raiser SN, Vincent KR. The aging musculoskeletal system and obesity-related considera- tions with exercise [ J ]. Ageing Res Rev, 2012, 11(3) :361-373.
  • 6Messier V, Rabasa-Lhoret R, Barbat-Artigas S, et al. Menopause and sarcopenia: A potential role for sex hormones [ J]. Maturitas, 2011, 68(4) :331-336.
  • 7Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance[J]. Science, 1993, 259(5091) :87-91.
  • 8Aguirre L, Napoli N, Waters D, et al. Increasing adiposity is associated with higher adipokine levels and lower bone mineral density in obese older adults [ J ]. J Clin Endocrinol Metab, 2014, 99(9):3290-3297.
  • 9Mundy GR. Osteoporosis and inflam- mation[J]. Nutr Rev, 2007, 65( 12 Pt 2) :S147-S151.
  • 10Zupan J, Jeras M, Marc J. Osteoim- munology and the influence of pro-in- flammatory cytokines on osteoclasts [ J]. Biochem Med (Zagreb),2013, 23(1) :43-63.

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