生活行为及性生活与前列腺癌危险性关系的病例对照研究

A case-control study on association between prostate cancer and life behavior and sexuality

目的探讨扬州地区前列腺癌与生活行为及性生活的病因学联系,为前列腺癌的科学防治提供理论依据。方法采用以医院为基础的1∶2配对病例对照研究,以确诊的前列腺癌病人为病例,分别以良性前列腺增生和其他疾病患者(排除泌尿系统疾病、冠心病及内分泌系统疾病的新发非癌病例)为对照,在扬州地区采用问卷方式,对性生活及吸烟,饮酒等生活方式进行调查,应用SPSS 13.0软件对资料进行分析。结果单因素分析显示,饮酒年限和饮茶种类,首次遗精年龄,首次性生活年龄及有手淫者与前列腺癌有统计学关联,而吸烟、饮酒量、饮酒类别,失去性生活年龄等因素与前列腺癌无统计学关联。多因素非条件Logistic回归分析显示,饮酒年限长、首次性生活年龄早、首次遗精年龄早、手淫与患前列腺癌危险性增加有关(P<0.05);饮茶则能降低前列腺癌危险性(P<0.05)。结论首次遗精年龄、性生活年龄越小,手淫越频繁,饮酒年限长者患前列腺癌的危险性大,而多喝绿茶是患前列腺癌的保护因素。

Objective To explore the association between prostate cancer and life behavior,sexual life. Methods A hospital based case-control study was conducted in the affiliated hospital of Yangzhou University. The patients with prostate cancer were chosen as cases. The cases and controls were matched by age, gender, nation and place of residence, All the subjects were interviewed with an identical questionnaire, including drinking, smoking and sexuality. The data were analyzed by SPSS 13.0 version. Results Single factor analysis showed that there was statistical relationship between drinking duration,tea varieties, spermatorrhea age, first sex age, masturbation and prostate cancer （ P〈 0. 05 ）. Multivariate Logistic regression analysis showed that drinking duration, spermatorrhea age, first sex age, masturbation were independem risk factors for prostate cancer （P〈0. 05）, and the diet of drinking tea was an independent protective factor for prostate cancer （P〈0. 05）. Conclusions The history of the first emission and intercourse at an earlier age, the habit of masturbation, long drinking duration are risk factors for prostate cancer. And drinking green tea is a protective factor for prostate cancer.