牙周基础治疗联合牙周支持治疗对药物性牙龈增生的疗效观察

Effect of initial periodontal therapy combined with supportive periodontal therapy on drug-induced gingival hyperplasia

目的评价牙周基础治疗联合牙周支持治疗对钙拮抗剂所致的牙龈增生的疗效。方法选择近3年来在本院因服用钙拮抗剂所致的牙龈增生患者30例,随机分为试验组和对照组各15例,在未停药换药的情况下,试验组行牙周基础治疗及牙周支持治疗,对照组仅行牙周基础治疗,在首次就诊和治疗后的1、3、6月比较分析2组患者的牙龈增生指数(GHI)、菌斑指数(PLI)、出血指数(BI)和探诊深度(PD)。结果试验组治疗后1、3、6月各项指标与基线比较差异有统计学意义(P<0.05),在观察期间各项指标持续好转无复发。对照组在牙周基础治疗后第1月各项指标与基线比较明显好转(P<0.05),但第3、6月后牙龈不良状况复发,与治疗前比较差异无统计学意义(P>0.05)。在第3、6月时,各项指标与同期试验组比较,差异有统计学意义(P<0.05),疗效较试验组差。结论牙周基础治疗可改善钙拮抗剂所致的牙龈增生情况,后期牙周支持治疗对预防复发有至关重要的作用。

Objective To evaluate the curative effect of initial periodontal therapy and supportive periodontal therapy on gingival hyperplasia induced by calcium channel blockers. Methods Thirty patients with gingival hyperplasia induced by calcium channel blockers were randomly divided into treatment group（ n = 15 ） and control group （n = 15 ）. In the ease of not changing or stopping drug, the patients of treatment group were given initial periodontal therapy and supportive periodontal therapy, and the patients of control group were given only initial periodontal therapy. The gingival hyperplasia index （ GHI）, plaque index （ PLI）, bleeding index （BI） and probing depth （ PD ） of the patients in the treatment of initial therapy, 1, 3 and 6 months after treatment were compared. Results During the observation period, GHI, PLI, BI and PD of the treatment group were significantly improved （ P〈0.05 ）. In control group, the indexes were significantly improved 1 month after treatment （P〈0. 05）. However, the bad conditions of gums arose once again and all the indexes were not significantly different from the baseline （P〉0.05） 3 and 6 months after treatment. The indexes of control group were signifi- cantly differed from those of the treatment group 3 and 6 months after treatment （P〈0.05）. Conclusions Initial periodontal therapy may successfully improve the extent of gingival hyperplasia induced by calcium channel blockers. Supportive periodontal therapy is effective to prevent gingival hyperplasia induced by calcium channel blockers from relapsing.