CKLF-1在特应性皮炎发病机制中的研究进展

Progress on CKLF-1 in the pathogenesis of AD

特应性性皮炎(AD)病因以及发病机制复杂,目前仍未完全明确。活化T淋巴细胞浸润为AD患者皮肤炎症皮损处特征,但是,目前仍不清楚浸润的是哪些T淋巴细胞亚群,如何被参与招募并聚集在皮损部位,发挥什么样免疫损伤作用。免疫学研究显示,趋化因子对于淋巴细胞的招募、聚集并发挥炎症反应至关重要。趋化因子是一类具有趋化活性的细胞因子,在机体的免疫调节、过敏反应、炎症反应、细胞增殖分化等过程中发挥重要作用,因此,本文围绕CKLF1(趋化素样因子1)与T淋巴细胞亚群及功能之间的关系,就CKLF-1在特应性皮炎发病机制中的研究进展作一综述。

Etiology and pathogenesis of atopic dermatitis （ AD） is complicated and remains unclear. The infiltra-tion of activated T lymphocytes is characteristic of the AD inflammatory skin lesion. However, what T lymphocyte sub-group involved, how they are recruited and gathered at the lesion site, its contribution to the immune injury, is still unclear. Immunological studies indicated that chemokines play an important role for lymphocyte recruitment, gather in and inflammatory response. Therefore, the progress of CKLF-1 in the pathogenesis of AD with regard to the relation-ship between CKLF1 （ chemokine like factor 1） and T lymphocyte subsets was reviewed in this paper.