miRNAs在年龄相关性黄斑变性的潜在作用

Potential role of miRNAs in age-related macular degeneration

大量的研究证实miRNAs在病理性血管生成、氧化应激反应、免疫反应以及炎症等病理生理过程中扮演着重要的作用,而这些病理生理过程是老年性黄斑变性(age-related macular degeneration,AMD)的发生发展中的关键过程。本文综述了AMD发生的病理机制及miRNAs在调节这些病理机制中的作用,讨论了基于miRNAs治疗AMD的应用前景。

A great number of miRNAs have been shown to play critical roles in pathological angiogenesis,the oxidative stress response,immune response and inflammation,all of which have been shown to have important roles in the pathogenesis and progression of age- related macular degeneration（ AMD）. Here we reviewed the pathological processes involved in AMD and the roles of miRNAs in these processes,and discussed potential miRNAs- based therapeutics for AMD.