拉坦前列素联合噻吗心安对开角型青光眼视觉功能、眼压、眼血流的影响

Effect of latanoprost combined with timolol treatment on visual function,intraocular pressure and ocular blood flow of open angle glaucoma

目的:研究拉坦前列素联合噻吗心安治疗方案对开角型青光眼视觉功能、眼压、眼血流的影响。方法:将2012-01/2014-05期间在我院眼科收治的开角型青光眼患者50例59眼纳入研究对象,采用数字表法随机分为观察组和对照组,观察组患者给予拉坦前列素联合噻吗心安治疗,对照组患者给予噻吗心安治疗,比较两组患者的视觉功能、眼压、眼血流情况。结果:治疗后1,2,3,4wk,观察组患眼白天平均眼压、夜间平均眼压均明显低于对照组,视力水平(0.27±0.03,0.36±0.06,0.44±0.06,0.63±0.13)明显高于对照组;观察组患眼的收缩期峰值血流速度(14.41±1.73cm/s)、舒张末期血流速度(4.18±0.67cm/s)均明显高于对照组,血管阻力指数(0.58±0.07)明显低于对照组。结论:拉坦前列素联合噻吗心安能够更为有效降低眼压,增加视网膜中央动脉的血流量,降低血管阻力,改善视力水平。

AIM： To study the effect of latanoprost combined with timolol treatment on visual function,intraocular pressure and ocular blood flow of open angle glaucoma.METHODS： A total of 50 cases（ 59 eyes） with open angle glaucoma were enrolled from January 2012 to May2014 in our hospital department of ophthalmology,and divided into observation group and control group by adopting the random number table method. Patients in observation group were treated with latanoprost combined with timolol,patients in control group were treated only with timolol. Visual function, intraocular pressure and ocular blood flow were compared.RESULTS： 1,2,3 and 4wk after treatment,observation group during the day intraocular pressure, night intraocular pressure were significantly lower than that in control group,vision levels（ 0. 27 ± 0. 03,0. 36 ± 0. 06,0. 44± 0. 06,0. 63 ± 0. 13） were significantly higher than that in control group; observation group peak systolic velocity（14.41±1.73） cm/s,end diastolic velocity（4.18±0.67） cm/s were significantly higher than that in control group;vascular resistance index（ 0. 58 ± 0. 07） was significantly lower than that in control group.CONCLUSION： Latanoprost combined with timolol treatment can reduce intraocular pressure,increase bloodflow of central retinal artery,reduce vascular resistance,improve visual acuity.