小梁切除术联合丝裂霉素和干扰素治疗新生血管性青光眼疗效观察

Clinical observation of trabeculectomy with mitomycin and interferon therapy on neovascular glaucoma

目的:探讨小梁切除术联合丝裂霉素和干扰素治疗新生血管性青光眼的临床效果。方法:对我院2011-01/2013-01收治的新生血管性青光眼患者进行抽样,选取患者57例57眼随机分成两组,对照组予以常规小梁切除术进行治疗,试验组予以小梁切除术+丝裂霉素+干扰素联合治疗,观察两组患者的临床疗效。结果:试验组总有效率(96%)明显优于对照组(76%),且视力、滤过泡及术后1wk;1a眼压变化情况优于对照组,差异具有显著统计学意义(P<0.05);试验组并发症发生率(10%)稍高于对照组(7%),但比较差异无统计学意义(P>0.05)。结论:小梁切除术联合丝裂霉素和干扰素治疗新生血管性青光眼临床效果确切,值得临床推广和应用。

AIM： To understand the clinical effect of trabeculectomy with mitomycin and interferon therapy on neovascular glaucoma.METHODS： Neovascular glaucoma patients in our hospital from January 2011 to January 2013 were sampled,from them,57 cases（ 57 eyes） were randomly divided into two groups, control group received routine trabeculectomy for treatment, the experimental group accepted combination therapy of trabeculectomy ＋mitomycin ＋ interferon. The clinical efficacy of two groups were observed.RESULTS： The total effective rate（ 96%） in experimental group was significantly better than that in the control group（ 76%）,and the visual acuity,filtering bleb and postoperative 1wk,1a of intraocular pressure changes were better than those of the control group,there was a statistically significant difference（ P 〈 0. 05）. The rate of complications in experimental group（ 10%） was slightly higher than that of the control group（7%）,but there was no statistically significant difference（ P 〉 0. 05）.CONCLUSION： Trabeculectomy combined mitomycin and interferon treatment of neovascular glaucoma has exact clinical effect, and is worthy of clinical popularization and application.