摘要
目的:探讨自体角膜缘干细胞移植联合低浓度丝裂霉素C对于合并2型糖尿病(T2DM)的翼状胬肉患者中的应用效果和安全性。方法:将本院收治的80例96眼翼状胬肉患者分为高浓度组、低浓度组、对照组,3组患者均给予翼状胬肉切除联合自体角膜缘干细胞移植,高浓度组、低浓度组在干细胞移植前分别给予0.2,0.1mg/mL丝裂霉素C棉片覆盖。比较3组患者的愈合和复发情况,以及治疗前后裸眼视力。结果:治疗前3组患者裸眼视力均无显著差异(P>0.05),3组患者治疗后裸眼视力均得到显著改善(P<0.05);高浓度组上皮愈合时间显著高于低浓度组和对照组(P<0.05),低浓度组和对照组上皮愈合时间无显著差异(P>0.05);低浓度组治愈率高于高浓度组,复发率低于高浓度组。结论:翼状胬肉切除联合自体角膜缘干细胞移植对于翼状胬肉疗效确切,联合丝裂霉素C能够有效降低复发率,但对于合并T2DM患者应当降低丝裂霉素C浓度。
AIM: To investigate effect and safety of the limbal stem cell transplantation combined with low concentrations of mitomycin C for pterygium patients with type 2 diabetes mellitus( T2DM).METHODS: Eighty patients of 96 pterygium eyes admitted to hospital were divided into groups of high concentration,low concentration group and the control group, and 3 groups were given pterygium excision combined with limbal stem cell transplantation. The high concentration group,the low concentration groups were given prior to stem cell transplantation 0. 2,0. 1mg /mL mitomycin C coverage. The cure rate and recurrence rate in three groups of patients,as well as visual acuity before and after treatment were compared.RESULTS: Three groups patients’ visual acuity were significantly improved after treatment( P 〈 0. 05),there was no significant difference before treatment in visual acuity( P 〉0. 05); epithelial healing time of high concentration group was significantly higher than low concentration group and the control group( P 〈 0. 05),there was no significant difference between low concentration and control groups of epithelial healing time( P 〉 0. 05); cure rates of low concentration group was higher than highdose group, the recurrence rate in low concentration group was lower than the high dose group.CONCLUSION: Pterygium excision combined with limbal stem cell transplantation has significant efficacy for pterygium,and mitomycin C can effectively reduce the relapse rate,but for the patients with T2 DM concentration of mitomycin C should be reduced.
出处
《国际眼科杂志》
CAS
2015年第1期167-169,共3页
International Eye Science