自体角膜缘干细胞移植联合丝裂霉素C在合并T2DM的翼状胬肉患者中的应用效果

Efficacy of limbal stem cell transplantation combined with mitomycin C in pterygium patients with T2DM

目的:探讨自体角膜缘干细胞移植联合低浓度丝裂霉素C对于合并2型糖尿病(T2DM)的翼状胬肉患者中的应用效果和安全性。方法:将本院收治的80例96眼翼状胬肉患者分为高浓度组、低浓度组、对照组,3组患者均给予翼状胬肉切除联合自体角膜缘干细胞移植,高浓度组、低浓度组在干细胞移植前分别给予0.2,0.1mg/mL丝裂霉素C棉片覆盖。比较3组患者的愈合和复发情况,以及治疗前后裸眼视力。结果:治疗前3组患者裸眼视力均无显著差异(P>0.05),3组患者治疗后裸眼视力均得到显著改善(P<0.05);高浓度组上皮愈合时间显著高于低浓度组和对照组(P<0.05),低浓度组和对照组上皮愈合时间无显著差异(P>0.05);低浓度组治愈率高于高浓度组,复发率低于高浓度组。结论:翼状胬肉切除联合自体角膜缘干细胞移植对于翼状胬肉疗效确切,联合丝裂霉素C能够有效降低复发率,但对于合并T2DM患者应当降低丝裂霉素C浓度。

AIM： To investigate effect and safety of the limbal stem cell transplantation combined with low concentrations of mitomycin C for pterygium patients with type 2 diabetes mellitus（ T2DM）.METHODS： Eighty patients of 96 pterygium eyes admitted to hospital were divided into groups of high concentration,low concentration group and the control group, and 3 groups were given pterygium excision combined with limbal stem cell transplantation. The high concentration group,the low concentration groups were given prior to stem cell transplantation 0. 2,0. 1mg /mL mitomycin C coverage. The cure rate and recurrence rate in three groups of patients,as well as visual acuity before and after treatment were compared.RESULTS： Three groups patients’ visual acuity were significantly improved after treatment（ P 〈 0. 05）,there was no significant difference before treatment in visual acuity（ P 〉0. 05）; epithelial healing time of high concentration group was significantly higher than low concentration group and the control group（ P 〈 0. 05）,there was no significant difference between low concentration and control groups of epithelial healing time（ P 〉 0. 05）; cure rates of low concentration group was higher than highdose group, the recurrence rate in low concentration group was lower than the high dose group.CONCLUSION： Pterygium excision combined with limbal stem cell transplantation has significant efficacy for pterygium,and mitomycin C can effectively reduce the relapse rate,but for the patients with T2 DM concentration of mitomycin C should be reduced.