慢性肾功能衰竭患者与干眼的相关性分析

Correlation analysis of chronic renal failure patients with dry eye

目的:探讨慢性肾功能衰竭(CRF)患者出现干眼的特点及影响因素,提供临床参考方法。方法:对我院61例122眼慢性肾功能衰竭患者(CRF组),与61例健康人员(对照组)两组人员进行泪液分泌试验(SchirmerⅠtest,SⅠt),泪膜破裂时间测定(BUT),角膜荧光素染色检查(FL),比较分析两组人员各项检查结果,分析CRF患者发生干眼的相关因素。结果:CRF组患者的泪液分泌试验值,泪膜破裂时间低于正常人群(P<0.05)。CRF组泪液分泌减少(SⅠt<10mm/5min)的比例为49.2%(60/122)高于对照组10.0%(12/122),两组比较差异有统计学意义(χ2=45.39,P<0.05)。CRF泪膜不稳定(BUT≤10s)的比例为75.4%(92/122),高于对照组27.0%(33/122),其差异有统计学意义(χ2=57.1,P<0.05)。角膜荧光染色(FL)阳性率为37.7%(46/122),高于对照组10.7%(13/122),两组差异有统计学意义(χ2=24.34,P<0.05)。结论:慢性肾功能衰竭患者泪液分泌减少,泪膜稳定性下降是干眼症的易患人群,临床上应注意对CRF患者干眼的治疗。

AIM： To investigate the clinical characteristics and influencing factors of chronic renal failure（ CRF） patients with dry eye,and to provide clinical reference.METHODS： Sixty- one cases（ 122 eyes） of patients with CRF（ CRF group） and 61 cases（ 122 eyes） of healthy persons（ control group） were carried out on Schirmer Ⅰtest（ SⅠt）,break- up time of tear film（ BUT）,corneal fluorescein staining（ FL）,test results of two groups were compared and related factors of dry eye in CRF patients were analyzed.RESULTS： The results of SⅠ t and BUT in CRF group were lower than that in the control group（ P 〈 0. 05）. The proportion of tear secretion reduce in CRF group（ SⅠ t 〈10mm /5min） was 49. 2%（ 60/122）,which was higher than that in the control group（ 10. 0%,12/122）, the difference was statistically significant（ χ2= 45. 39,P 〈0. 05）. The percentage of instability of tear film in CRF group（ BUT ≤ 10s） was 75. 4%（ 92/122）,which was significantly higher than that in the control group（ 27. 0%,33/122）（ χ2= 57. 1,P 〈0.05）. The positive rate of corneal FL was 37. 7%（ 46/122）,which was higher than that of the control group（ 10. 7%,13/122）,there w as a statistically significant difference（ χ2= 24. 34,P 〈 0. 05）.CONCLUSION： CRF patients with a decrease in tear film stability and tear secretion are susceptible population to dry eye, clinically should be paid attention to the treatment.