血清降钙素原与超敏C-反应蛋白联合检测诊断老年下呼吸道感染的临床价值

Clinical value of serum procalcitonin and C-reactive protein combined detection for diagnosis of senile lower respiratory tract infection

目的评价血清降钙素原(PCT)与超敏C-反应蛋白(hs-CRP)联合检测对于诊断老年下呼吸道细菌性感染的临床应用价值,为临床治疗提供参考依据。方法选取医院于2011年1月-2012年12月收治的120例老年细菌性呼吸道染患者作为观察组,同期选取120名老年非细菌性呼吸道染患者作为感染对照组与120名正常老年人为正常对照组;对比3组老年人血清中PCT和hs-CRP的含量,采用SPSS19.0进行统计分析。结果观察组患者的血清中PCT和hs-CRP含量明显高于感染对照组和正常对照组(P<0.01);感染对照组患者的血清中PCT和hs-CRP含量明显高于正常对照组(P<0.01);PCT与hs-CRP单独用于诊断老年下呼吸道细菌性感染的灵敏度分别为84.3%、88.9%。结论 PCT和hs-CRP可以用于诊断老年下呼吸道感染,联合检测诊断的特异性比较高,值得临床推广。

OBJECTIVE To evaluate the clinical value of serum procalcitonin （PCT ） and supersensitive C‐reactive protein （hs‐CRP） combined detection for the diagnosis of senile bacterial infection in lower respiratory tract so as to provide reference for clinical treatment .METHODS Totally 120 senile patients with bacterial respiratory infec‐tion admitted in our hospital in Jan .2011 to Dec .2012 were assigned as the observation group ,120 senile patients with non‐bacterial respiratory infection during the same period as the infective control group and another 120 nor‐mal senile people as the normal control group .Three groups were compared for serum PCT and hs‐CRP levels . The software SPSS19 .0 was used for statistical analysis .RESULTS The serum PCT and hs‐CRP were significantly higher in the observation group than the infective control group and the normal control group （P＆lt;0 .01） .These two indicators were significantly higher in the infective control group than in the normal control group （P＆lt;0 .01） . Sensitivity of PCT and hs‐CRP alone for the diagnosis of senile bacterial infection in lower respiratory tract was 84 .3% and 88 .9% .CONCLUSION PCT and hs‐CRP can be used for diagnosis of senile lower respiratory tract in‐fection ,their combined detection has relatively high diagnostic specificity which is worthy of promotion .