垂体腺苷酸环化酶激活肽与支气管哮喘

Pituitary adenylate cyclase activating polypeptide and bronchial asthma

支气管哮喘（简称哮喘）是儿童最常见的慢性疾病之一，对儿童的健康造成很大威胁。气道慢性炎症、气道高反应性及气道重塑是哮喘的基本特征。大量的研究发现垂体腺苷酸环化酶激活肽（PACAP）具有多种生物学活性，参与免疫调节、炎症反应、呼吸节律、氧化应激等。明确PACAP在哮喘中的发病机制，有望成为哮喘药物研究的新方法和新策略。

Bronchial asthma （asthma） is one of the most common chronic disease of children, causing great threat to the heahh. Chronic airway inflammation,bronchial hyperresponsiveness and airway remodeling are essential characteristic of asthma. Many studies found that pituitary adenylate cyclase activating polypeptide （PACAP） with multiple biological activities, involved in immune regulation, inflammation,respiratory rhythm, oxidative stress. Clear PACAP in asthma pathogenesis, is expected to become the asthma drug research new methods and new strategies.