绝经后2型糖尿病患者骨质疏松相关因素分析

Analysis of Related Factors of Osteoporosis in Postmenopausal Women with Type 2 Diabetic

目的探讨绝经后2型糖尿病患者骨密度(BMD)变化及其相关因素。方法采用双能X线骨密度仪获取41例绝经后2型糖尿病患者的正位腰椎(L1-4)、左侧股骨BMD数据,根据是否合并骨质疏松,分为骨质疏松组(OP组)23例,非骨质疏松组((NOP组)18例。观察比较两组间身高、体重、体重指数(BMI)、血清钙、血清磷含量和糖化血红蛋白含量(Hb A1c)的差异,并进行相关性分析。结果 OP组体重、体重指数、Hb A1c与NOP组比较,差异显著有统计学意义(P<0.05),而两组血清钙、血清磷、身高无明显差异(P>0.05);多因素相关分析显示:BMD与Hb A1c呈负相关;与体重、BMI呈正相关。结论 Hb A1c、体重、BMI是影响绝经后2型糖尿病患者BMD重要因素,在防治绝经后2型糖尿病骨质疏松患者过程中应积极控制血糖,并监测体重、体重指数。

Objective To investigate the related factors of the postmenopausal bone mineral density （ BMD） in patients with type 2 diabetes mellitus. Methods The dual energy X-ray absorptiometry was used to get the BMD value of the lumbar spine （ L1-4 ） and left femur in 41 cases of postmenopausal women with type 2 diabetic. According to whether the patients suffered from osteoporosis or not, they were divided into osteoporosis group （ OP group, n=23 ） and non-osteoporosis group （ NOP group n=18 ） . The height, weight, body mass index （ BMI） , serum calcium, serum phosphorus content and glycosylated hemoglobin content （ HbA1 c） of the two groups were observed and compared, and relevance analysis was carried out. Results There was difference between the OP group and NOP group in the body weight, body mass index and HbA1 c which was statistically significant （ P〈0. 05 ） . However, there was no difference in the serum calcium, serum phosphorus and height of the two groups （P〉0. 05）. The related factors analysis showed that the BMD was negatively correlated with HbA1 c, but positively related with the weight and BMI. Conclusion The HbA1 c, body weight and BMI are the important factors that influence the BMD of postmenopausal patients with type 2 diabetes, which hint that active control of the blood glucose, body weight and body mass index is the important measure to prevent the postmenopausal osteoporosis in patients with type 2 diabetes mellitus.